Objective: To develop the study on pharmacokinetics of Tougu Xiaotong capsules after single and multiple oral administration in rats

to discuss relevance between plasma concentration and pharmacokinetic parameters in different ways of administration

which provides basis for the clinical rational use of traditional Chinese medicine compound. Method: SD rats were randomly divided into 2 groups

including single and multiple administration group

respectively.After intragastrical administration of Tougu Xiaotong capsules

according to the area under absorbance-wavelength curve (AUAWC) being proportional to the total concentration of total solid overall composition

AUAWC was used to measure overall composition content of the capsules.The blood drug concentration data were processed in DAS 2.0 pharmacokinetic software;after single and multiple oral administration

pharmacokinetic parameter and the steady-state plasma concentration were calculated by compartment model. Result: After single oral administration

Cmax was (10.200±0.586) mg·L-1

tmax was (0.515±0.054) h

t1/2 was (1.318±0.049) h and AUC0-24 h was (13.054±0.422) mg·h·L-1

respectively.Steady-state plasma concentration was achieved after 6 d in the multiple oral administration group

Cav was (4.073±0.282) mg·L-1

DF was 1.166±0.175 and AUCss was (48.878±1.931) mg·h·L-1

respectively. Conclusion: Change of plasma concentration after multiple oral administration of Tougu Xiaotong capsules is in a good steady-state process

it is consistent with in vivo behaviour of the single oral administration group

which shows rationality in the clinical dosage of Tougu Xiaotong capsules.