HUANG Hai-yan, ZHU He, HAN Bin, et al. Estblish Fingerprint of Medicated Plasma of Buyanghuanwu Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 96-99.
DOI:
HUANG Hai-yan, ZHU He, HAN Bin, et al. Estblish Fingerprint of Medicated Plasma of Buyanghuanwu Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 96-99. DOI: 10.13422/j.cnki.syfjx.2016150096.
Estblish Fingerprint of Medicated Plasma of Buyanghuanwu Tang
Objective: In order to establish the plasma HPLC fingerprints of Buyanghuanwu Tang(BYHWT) and to further explore its pharmacodynamic material basis. Method: The prototype components and metabolites in rat plasma were identified through comparing the fingerprints of BYHWT
rat plasma-containing active components and blank plasma. Result: After the ig administration of BYHWT
30 main components into blood were marked in the plasma fingerprint
10 came from the original compound of rat plasma
one peak was the solvent peak. Other 19 were the drug-induced compositions
4 of which were prototype constituents
other 15 were metabolites
such as 2 metabolites from Astragali Radix
1 metabolite from Semen Persicae. Conclusion: The method established in this study was accurate
reliable
and can be used to research the BYHWT plasma fingerprint and efficacy material foundation.
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