Objective: To investigate the clinical curative of Quyidi prescription in patients with type 2 diabetes mellitus (T2DM) in a hypercoagulable state. Method: Totally 60 patients were randomly divided into two groups by using the digital table method. The traditional Chinese medicine(TCM) group was treated with TCM decoction

2 times per day

the control group was orally treated with oral sodium phosphate ligustrazine hydrochloride

50 mg/time

tid. After 4 weeks

their tissue factor (TF)

blood rheology

coagulation function

platelet aggregation rate

blood lipid

blood glucose and other related indicators of TCM symptom scores were observed for a statistical analysis and comparison for efficacies. Result: In the aspect of tissue factors

the treatment group was superior to the control group (P<0.01)

which indicated that the TF level of the treatment group was significantly higher than that of the control group. After treatment

the blood rheological indexes of both groups were reduced (P<0.05)

and the treatment group was superior to the control group (P<0.05). In terms of blood coagulation function

and blood lipid and blood glucose levels

both groups showed obvious alleviations(P<0.05

P<0.01)

and the treatment group was superior to the control group. Meanwhile

the treatment group was significantly better than the control group in the efficacy of TCM syndrome. There was no adverse event and reaction during the trial period. Conclusion: The Qi supplementing

Yin nourishing

promoting blood activating and phlegm expelling therapy can effectively decrease the plasma levels of TF in T2DM patients

and alleviate blood lipid and blood coagulation indexes

at the same time

it can alleviate glucose and lipid metabolic disorder

and TCM syndrome scores among T2DM patients

in order to improve the quality of life.