Objective: To evaluate the clinical effect of renal failure recipe on renal function and fibrosis in patients with early and middle-term chronic renal failure. Method: Totally 60 cases of patients with three and four-stage chronic kidney disease (spleen and kidney deficiency

blood stasis type) were selected and randomly divided into control group and treatment group. The former received losartan in addition to western medicine integration treatment

while the latter was given renal failure recipe in addition to the former's therapy. After 6 months of treatment

we observed the changes in traditional Chinese medicine (TCM) syndrome scores and curative effect

therapeutic efficacy

hemoglobin

renal function

24-hour urine protein

connective tissue growth factor(CTGF) and bone morphogenetic protein-7 (BMP-7) in the two groups of patients. Result: The curative effect of TCM syndrome and curative effect of treatment group were obviously superior to that of control group (P<0.01). Treatment group was superior to control group in reduction in 24-hour urine protein and creatinine and increase in glomerular filtration rate (P<0.05

P<0.01). The two groups showed significant reduction in serum CTGF levels (P<0.05)

and increase in blood bone morphogenetic protein-7 (BMP-7) level (P<0.05). Conclusion: Renal failure recipe shows an obvious clinical curative effect in treating patients with early and middle-term chronic renal failure compared with the control group

and can reduce proteinuria

alleviate renal function

and prevent renal fibrosis. Its mechanism may be related to the down-regulation of serum CTGF and upregulation of BMP-7 expression.