Objective: To make the systematic review and Meta-analysis for the effect of post-laparoscopic oral administration with Danzhu Xiaoyi decoction on the pregnancy

abortion and recurrence of treating patients with endometriosis (EMT). Method: Randomized controlled trials (RCTs) and controlled trials (CCTs) related to the effects of post-laparoscopic oral administration with Danzhu Xiaoyi decoction for EMT were collected in CNKI

CBM

VIP Wanfang database and PubMed (before August 2015). The quality of the RCTs and CCTs were assessed using Cochrane systematic review

involving selection bias

performance bias

measurement bias

attrition bias

and reporting bias. The overall effect of multiple findings was studied by using RevMan 5.3 software through a Meta-analysis for a fixed effects model

and then heterogeneity evaluation and sensitivity analysis were conducted. Result: A total of 4 literatures were included. According to the results of the Meta-analysis

compared with pure laparoscopic surgery

post-laparoscopic oral administration with Danzhu Xiaoyi decoction for EMT had a significantly higher pregnancy (I2=0%)

lower heterogeneity [RR=1.47

95%CI (1.13

1.90)]

with significance test Z=4.96 (P<0.000 01). At the same time

it had an obviously lower the incidence of spontaneous abortion (I2=0%)

lower heterogeneity [RR=0.29

95%CI (0.09

0.92)]

with significance test Z=2.28 (P=0.02). In addition

there were a significantly lower incidence of recurrence (I2=0%)

lower heterogeneity [RR=0.23

95%CI(0.07

0.78)]

with significance test Z=2.36 (P=0.02). Conclusion: Post-laparoscopic oral administration with Danzhu Xiaoyi decoction could improve the pregnancy rate and reduce the incidence of spontaneous abortion as well as recurrence. However

it is still necessary to carry out high-quality three-blinded RCT with a large sample size.