Meta-analysis of Wenxin Granules Combined with Bisoprolol in Treatment of HF-induced

SHI Shuai; GENG Yan-ting; HU Yuan-hui; SONG Qing-qiao; DU Bai; FENG Rui

doi:10.13422/j.cnki.syfjx.2016150216

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Meta-analysis of Wenxin Granules Combined with Bisoprolol in Treatment of HF-induced

更新时间：2024-09-23

- Meta-analysis of Wenxin Granules Combined with Bisoprolol in Treatment of HF-induced
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 15, Pages: 216-219(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016150216
  CLC： R541
- Published：2016
- 稿件说明：
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SHI Shuai, GENG Yan-ting, HU Yuan-hui, et al. Meta-analysis of Wenxin Granules Combined with Bisoprolol in Treatment of HF-induced[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 216-219.
DOI：

SHI Shuai, GENG Yan-ting, HU Yuan-hui, et al. Meta-analysis of Wenxin Granules Combined with Bisoprolol in Treatment of HF-induced[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 216-219. DOI： 10.13422/j.cnki.syfjx.2016150216.

摘要

目的：对稳心颗粒联合比索洛尔治疗心力衰竭合并心律失常的随机对照试验（RCT）质量进行疗效的评估，为临床实践提供循证医学证据。方法：通过计算机检索PubMed，EMbase，Cochrane图书馆，CNKI，万方数据库，VIP等数据库中相关文献（检索时限均为建库至 2015 年 5 月 10日），筛选出稳心颗粒联合比索洛尔治疗心力衰竭合并心律失常的RCT，并使用RevMan 5.3软件进行Meta分析。结果：共检索相关文献279篇，筛选后纳入6个RCT，共计527例患者。Meta分析结果显示：对心力衰竭合并心律失常患者的心律失常改善显效率[OR=3.85，95%CI（2.39，6.20），P<0.000 01]和心悸症状改善显效率[OR=4.48，95%CI（2.42，8.30），P<0.000 01]，治疗组（稳心颗粒+比索洛尔）大于对照组（比索洛尔）；治疗组的药物不良反应的发生率[OR=0.42，95%CI（0.18，1.01），P=0.05]小于对照组。各组有效率的数据差异有统计学意义。结论：联用稳心颗粒与比索洛尔较单独使用比索洛尔治疗心力衰竭合并心律失常疗效更显著，并减少了不良反应。

Abstract

Objective: To evaluate the efficacy and safety of combined treatment of Wenxin granules and bisoprolol in treating arrhythmias induced by heart failure (HF). Method: Literatures were searched in PubMed

EMbase

CNKI

Cochrane Central Register of Controlled Trials

Wanfang and VIP database (since the establishment to May 10

2015) to select qualified RCTs. RevMan 5.3 software was used to make a Meta-analysis. Result: Totally 279 relevant literatures

involving 6 RCTs (527 patients)

were selected and included in this study. According to the results of the meta-analysis

the cardiac failure-arrhythmias group showed a higher rate in improving arrhythmia frequency than the control group [OR=3.85

95%CI (2.39

6.20)

P<0.000 01]

and in improving palpitations than the control group [OR=4.48

95%CI (2.42

8.30)

P<0.000 01]. The combined treatment group (Wenxin granules + bisoprolol) showed a lower rate of adverse events than the control group [OR 0.42

95%CI (0.18

1.01)

P<0.05]. Conclusion: Combined treatment with Wenxin granules and bisoprolol is more effective and causing less adverse events than the use of only bisoprolol for treating HF-induced ventricular arrhythmias.

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