Objective: To determine ferulic acid in Angelicae Sinensis Radix by HPLC

while establishing their fingerprints to explore differences in ferulic acid content and fingerprint between the original drugs and the medicinal powder after the blending

in order to find ways to standardize the quality of drugs. Method: The blending target for ferulic acid is 130%according to pharmacopoeia standards. The reference fingerprint is based on nine different batches of Angelicae Sinensis Radix. Fingerprints and ferulic acid data were collected after the blending. Result: After blending

content result was close to the target

with a deviation of less than ±10%

and the fingerprint similarity after the blending was above 0.980. Conclusion: After different batches of pieces were processed by stepwise blending method

the index component content was close to the target

and fingerprint similarity became consistent

indicating that the quality consistency of Chinese materia medica increased significantly. The method was accurate and simple

with no need to use complexity mathematical software

and so can be used as a new method for blending Chinese materia medica pieces.