Clinical Observation of Qingfei Huazhuo Decoction in Treatment of Pulmonary Infection in Malignant Tumors

MA Dong-yang; GUO Xuan-xian; HU Yan-hui; CUI Qing-li

doi:10.13422/j.cnki.syfjx.2016160168

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Clinical Observation of Qingfei Huazhuo Decoction in Treatment of Pulmonary Infection in Malignant Tumors

更新时间：2024-01-04

- Clinical Observation of Qingfei Huazhuo Decoction in Treatment of Pulmonary Infection in Malignant Tumors
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 16, Pages: 168-171(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016160168
  CLC： R273
- Published：2016
- 稿件说明：
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MA Dong-yang, GUO Xuan-xian, HU Yan-hui, et al. Clinical Observation of Qingfei Huazhuo Decoction in Treatment of Pulmonary Infection in Malignant Tumors[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(16): 168-171.
DOI：

MA Dong-yang, GUO Xuan-xian, HU Yan-hui, et al. Clinical Observation of Qingfei Huazhuo Decoction in Treatment of Pulmonary Infection in Malignant Tumors[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(16): 168-171. DOI： 10.13422/j.cnki.syfjx.2016160168.

摘要

目的：观察清肺化浊汤治疗恶性肿瘤患者合并肺部感染的临床疗效，探讨其作用机制。方法：收集2014年1月-2015年2月河南省肿瘤医院中西医科恶性肿瘤合并肺部感染患者76例，按照随机数字表法随机分为对照组和治疗组，各38例。对照组给予常规抗生素并一般对症支持治疗。治疗组在对照组治疗基础上，加服清肺化浊汤，治疗1周后评价临床疗效，观察两组患者血常规和肺部影像学，检测两组患者血清中的C-反应蛋白（CRP）和降钙素原（PCT）变化。结果：治疗组总有效率（86.8%）高于对照组（65.8%）（P<0.05）。治疗组的体温和肺部啰音恢复正常的时间短于对照组（P<0.05）。治疗组血常规和肺部影像学恢复正常时间短于对照组（P<0.05）。两组患者血清中的CRP和PCT治疗后均下降（P<0.05），治疗组改善更加明显（P<0.05）。结论：清肺化浊汤结合常规西医治疗恶性肿瘤合并肺部感染效果显著，优于常规西医治疗。

Abstract

Objective: To observe the clinical efficacy of Qingfei Huazhuo decoction on pulmonary infection in malignant tumors

and explore its possible mechanisms. Method: The 76 patients with pulmonary infection in malignant tumors from January 2014 to February 2015 in integrative department of Henan Cancer Hospital were included in this study

and divided into control group (38 cases) and treatment group (38 cases) by random number table. Patients in control group received routine antibiotics and conventional treatment. Based on the treatment in control group

patients in treatment group received additional Qingfei Huazhuo decoction. Patients were given with corresponding drugs for another 1 week. Then the clinical efficacy was evaluated

routine blood and lung imaging results were observed in both groups

changes in C-reactive protein (CRP) and procalcitonin (PCT) in serum of both groups were detected. Result: The total effective rate was 86.8%in treatment group

higher than 65.8% in control group (P<0.05).The recovery time of body temperature and pulmonary rales in treatment group was less than that in control group (P<0.05)

and the recovery time of routine blood test and lung imaging in treatment group was less than that in control group (P<0.05). After the treatment

both groups showed lower expressions of CRP and PCT in serum (P<0.05)

and the improvement was more obvious in treatment group (P<0.05). Conclusion: Qingfei Huazhuo decoction combined with routine western treatment is more effective than the routine western treatment alone for pulmonary infection in malignant tumors.

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