Objective: To investigate the efficacy of Bushen Tiaochong decoction in treating peri-menopausal dysfunctional uterine bleeding (DUB) with syndrome of kidney-Yang deficiency and its influences on levels of serum follicle stimulating hormone (FSH)

luteinizing hormone (LH) and estrogen (E2). Method: Peri-menopausal DUB cases treated in our hospital were selected and randomly divided into control group and treatment group. Forty-six patients in control group were given mifepristone from the 3rd day after diagnostic curettage every night before sleep by oral (12.5 mg/time

qd). In addition to the therapy of control group

47 patients in treatment group were treated with Bushen Tiaochong decoction (1 dose/day

bid). The courses of treatment were 3 months for both groups. Bleeding stop time

recurrence rates

traditional Chinese medicine (TCM) symptom integrals and clinical efficacies were compared between both groups. Serum levels of FSH

LH and E2 were detected in the two groups. Result: Bleeding stop time in treatment group were lower than control group after treatment (P<0.01). In the follow-up visit 3 months later

the recurrence rate of treatment group was 2.13%

which was evidently lower than 15.22%of control group (P<0.01). After treatment

the scores of depression

lack of warmth in the limbs

soreness and weakness of waist and knees

more urinate at night in treatment group were more significantly decreased

which were evidently lower than control group (P<0.01). Clinical total effective rate of treatment group was 95.74%

was higher than 80.43%of control group (P<0.05). After treatment

serum levels of FSH and LH in treatment group were significantly lower than control group

but with a higher E2 (P<0.01). Conclusion: In addition to the western medicine routine treatment

Bushen Tiaochong decoction in treating peri-menopausal DUB with syndrome of kidney-Yang deficiency could obviously reduce the bleeding stop time

recurrence rate

TCM symptoms score

improve clinical efficacy

and inhibition of serum levels of FSH and LH and up-regulation of E2 may play an important role in the above effects.