Chemical Constituents of Atractylodis Macrocephalae Rhizoma

ZOU Hui; YANG Chen; YI Mei-ling; WU Fu-xuan; SHENG Xi-feng; FENG Xing

doi:10.13422/j.cnki.syfjx.2016170043

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Chemical Constituents of Atractylodis Macrocephalae Rhizoma

更新时间：2024-01-04

- Chemical Constituents of Atractylodis Macrocephalae Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 17, Pages: 43-48(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016170043
  CLC： R284
- Published：2016
- 稿件说明：
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ZOU Hui, YANG Chen, YI Mei-ling, et al. Chemical Constituents of Atractylodis Macrocephalae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(17): 43-48.
DOI：

ZOU Hui, YANG Chen, YI Mei-ling, et al. Chemical Constituents of Atractylodis Macrocephalae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(17): 43-48. DOI： 10.13422/j.cnki.syfjx.2016170043.

摘要

目的：对白术乙酸乙酯提取物的化学成分进行研究。方法：采用多种现代色谱技术进行分离纯化，通过理化性质及光谱方法鉴定化合物的结构。噻唑蓝（MTT）法对所得化合物进行细胞毒活性测试。结果：从白术的乙酸乙酯提取物中分离得到16个化合物，分别鉴定为1-乙酰氧基-6E，12E-二烯-8，10-二炔-3-醇（1），3-乙酰氧基-6E，12E-二烯-8，10-二炔-1-醇（2），6E，12E-十四碳二烯-8，10-二炔-1，3-二醇乙酸酯（3），12-异戊烯酰氧基-14-乙酰氧-2E，8Z，10E-三烯-4，6-二炔-1醇（4），12-异戊烯酰氧基-14-乙酰氧-2E，8E，10E-三烯-4，6-二炔-1醇（5），白术内酯I（6），白术内酯Ⅱ（7），白术内酯Ⅲ（8），双白术内酯（9），杜松脑（10），蒲公英萜醇乙酸酯（11），3β-乙酰氧基-12-齐墩果烯-11酮（12），7-羟基香豆素（13），二十八烷酸（14），十七烷酸（15），7-α-羟基-β-谷甾醇（16）。结论：化合物1，2，16为首次从白术中分离得到，化合物12～15为首次从苍术属植物中分离得到，化合物6对宫颈癌HeLa细胞系具有较好抑制作用，IC50为15.6 μmol·L-1。

Abstract

Objective: To study the chemical constituents of Atractylodis Macrocephalae Rhizoma. Method: The compounds were isolated and purified from ethyl acetate extract of Atractylodis Macrocephalae Rhizoma by using a combination of chromatographic techniques. Their structures were elucidated on the basis of thierphysico-chemical properties and spectroscopic data analyses. MTT method was used to assay the cytotoxicity agianst HeLa cells. Result: Sixteen compounds were isolated and purified from ethyl acetate extract of Atractylodis Macrocephalae Rhizoma and determined as 1-acetoxytetradeca-6E

12E-dien-8

10-diyn-3-ol (1)

3-acetoxytetradeca-6E

12E-dien-8

10-diyn-1-ol (2)

tetradeca-6E

12E-dien-8

10-diyn-1

3-diol diacetate (3)

14-acetoxy-12-senecioyloxytetradeca-2E

10E-trien-4

6-diyn-1-ol (4)

14-acetoxy-12-senecioyloxytetradeca-2E

10E-trien-4

6-diyn-1-ol (5)

atractylenolide Ⅰ (6)

atractylenolide Ⅱ (7)

atractylenolide Ⅲ (8)

biatractylenolide (9)

juniper camphor (10)

taraxerylacetate (11)

3β-acetoxy-12-oleanen-11-one (12)

7-hydroxy coumarin (13)

octacosanic acid (14)

heptadecanoic acid (15)

7-α-hydroxyl-β-sitosterol (16). Conclusion: Among them

compounds 1

16 were isolated from the species firstly and compounds 12-15 were isolated from the genus of Atractylodes for the first time. Compound 6 showed good inhibitory activity against HeLa cells with IC50 values of 15.6μmol ·L-1.

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