Objective: To study the effect of Shierwei Chuanjia tablets on immunological hepatic fibrosis in rat models. Method: The male SD rats were randomly divided into normal group

model group

positive drug group (colchicine tablets

0.1 mg · kg-1)

and Shierwei Chuanjia tablets groups (2.8

1.4

0.7 g · kg-1). In all the other groups except normal group

pig serum was used to prepare the rat models of immunological hepatic fibrosis. At the same time

the rats received corresponding anti hepatic fibrosis interventions for a total of 6 weeks. The effects of drugs were observed by calculating the body mass and liver index

detecting liver function alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

total protein(TP)

albumin(ALB)

globulin(GLO)

and albumin globulin ratio (A/G). hyaluronate (HA) levels in serum were measured by using ELISA. HE staining was used to observe the pathological changes of liver tissues and Masson staining was used to observe the proliferation of collagen fibers. Result: As compared with the normal group

ALT and HA levels in serum of model rats were significantly increased

and liver indexes were also significantly increased (P<0.01); ALB and A/G were significantly decreased (P<0.01); the pathological changes of liver tissues were more obvious in model group. As compared with the model group

The other groups of Shierwei Chuanjia tablets had no significant effect on the changes of serum AST and GLO levels

but could significantly decrease the serum ALT and HA levels in liver fibrosis rats (P<0.01)

increase the levels of serum TP

ALB and A/G

and can significantly reduce the pathological changes of liver tissues

with the most significant effect in 2.8 g · kg-1Shierwei Chuanjia tablets group. Conclusion: Shierwei Chuanjia tablets can significantly improve the hepatic fibrosis in model rats

showing certain anti-hepatic fibrosis effect.