Objective: Toreveal the traditional Chinese medicine (TCM) syndromerules of diabetic peripheral vascular disease

and provide reliable and objective basis for clinical diagnosis and treatment. Method: Based on the TCM symptoms

898 patients with diabetic peripheral angiopathy were divided into 3 groups

Qi and Yin deficiency with blood stasis group

Qi and Yin deficiency with dampness-heat group and Yin and Yang deficiency group. Different tests were carried out to examine the differences among groups on fasting plasma glucose (FPG)

2 hour postprandial blood glucose (2 h PG)

glycosylated hemoglobin (HbAlc)

blood fat

fibrinogen

packed red cell volume and vascular ultrasound

et al. Result: There was no difference in the levels of FPG

2 h PG and HbAlc among groups. The levels of waistline

hip circumference

waist/hip ratio

body weight

body mass index (BMI)

triglyceride

cholesterol

low density lipoprotein

fibrinogen and packed red cell volume were significantly higher in Yin and Yang deficiency group (P<0.05

P<0.01)

followed by Qi and Yin deficiency with dampness-heat group

and the values were lowest in Qi and Yin deficiency with blood stasis group. Vascular ultrasound showed that the blood flow volume of dorsal artery of foot in Yin and Yang deficiency group was significantly lower than that of Qi and Yin deficiency with dampness-heat group (P<0.05). In addition

calibers of femoral artery and popliteal artery were gradually narrowed and blood flow volume was gradually reduced in turn from Qi and Yin deficiency with blood stasis group

Qi and Yin deficiency with dampness-heat group to Yin and Yang deficiency group. Conclusion: The Yin and Yang deficiency was the most severe stage of diabetic peripheral vascular disease

followed by Qi and Yin deficiency with dampness-heatand then Qi and Yin deficiency with blood stasis.The occurrence regularity of diabetic peripheral vascular disease was revealed so as to provide reliable theoretical basis for clinical classification

and it was good for determining the treatment based on differentiation of symptoms and signs.