Objective: To investigate the mechanism of Jinzhen oral liquid for respiratory tract infection by using network pharmacology method. Method: The structures of small molecule compounds of Jinzhen oral liquid were downloaded from database; molecular descriptors were calculated to study the chemical space distribution of these compounds. After that

the interactions between those compounds and target proteins related to respiratory infections were studied by molecule docking method. Then the "drug-target network" was constructed to predict the main active ingredients and action targets of Jinzhen oral liquid in the treatment of respiratory tract infection. Result: The 651 compounds of Jinzhen oral liquid showed good drug-like properties. Network analysis results showed that

120 compounds of Jinzhen oral liquid were strongly interacted with 23 targets related to respiratory tract infection. Furthermore

11 active compounds and 18 potential targets of Jinzhen oral liquid were predicted for treating respiratory tract infection. Conclusion: The effect of Jinzhen oral liquid for respiratory tract infection may be associated with the adsorption

replication

and uncoating of virus (influenza virus

nasal virus) infections

as well as interfering the inflammation related signaling pathways and regulating the secretion of inflammatory mediators.