Comparison of Contents of Verbascoside and Isoverbascoside in Plantaginis Semen and Plantaginis Herba

XU Bing-bing; HUANG Bi-tao; ZENG Jin-xiang; LI Min; WANG Juan; ZHU Yu-ye; REN Gang; ZHU Ji-xiao; LUO Guang-ming; WANG Xiao-yun

doi:10.13422/j.cnki.syfjx.2016180064

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Comparison of Contents of Verbascoside and Isoverbascoside in Plantaginis Semen and Plantaginis Herba

更新时间：2024-01-04

- Comparison of Contents of Verbascoside and Isoverbascoside in Plantaginis Semen and Plantaginis Herba
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 18, Pages: 64-67(2016)
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- DOI：10.13422/j.cnki.syfjx.2016180064
  CLC： O657.72;R284.1
- Published：2016
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XU Bing-bing, HUANG Bi-tao, ZENG Jin-xiang, et al. Comparison of Contents of Verbascoside and Isoverbascoside in Plantaginis Semen and Plantaginis Herba[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(18): 64-67.
DOI：

XU Bing-bing, HUANG Bi-tao, ZENG Jin-xiang, et al. Comparison of Contents of Verbascoside and Isoverbascoside in Plantaginis Semen and Plantaginis Herba[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(18): 64-67. DOI： 10.13422/j.cnki.syfjx.2016180064.

摘要

目的：分析比较车前子及车前草中毛蕊花糖苷、异毛蕊花糖苷含量差异，为车前质量控制与临床用药提供实验依据。方法：采用反相高效液相色谱法（RP-HPLC），Diamonsil C18色谱柱（4.6 mm×250 mm，5 μm），流动相甲醇-0.1%甲酸水溶液（40：60），同时测定车前子及车前草中毛蕊花糖苷、异毛蕊花糖苷的含量，流速0.6 mL·min-1，柱温25℃，检测波长330 nm。结果：车前子与车前草中毛蕊花糖苷质量分数分别为9.70，0.32 mg·g-1，异毛蕊花糖苷质量分数分别为1.28，1.51 mg·g-1。结论：车前子中毛蕊花糖苷含量高于车前草，异毛蕊花糖苷含量低于车前草，临床应合理用药，并建议车前增加异毛蕊花糖苷为质控指标。

Abstract

Objective: To analyze and compare the content differences of verbascoside and isoverbascoside in Plantaginis Semen and Plantaginis Herba

and provide experimental basis for quality control and clinical application of plantain. Method: A RP-HPLC method was applied for the content determination with a Diamonsil C18 column (4.6 mm×250 mm

5 μm) at 25℃. Methanol-0.1% formic acid aqueous solution(40:60) was used as mobile phase; the flow rate was 0.6 mL·min-1

and the detection wavelength was set at 330 nm. Result: Content of verbascoside in Plantaginis Semen was 9.70 mg·g-1 and 1.28 mg·g-1

respectively; and isoverbascoside was 0.32 mg·g-1 and 1.51 mg·g-1

respectively in Plantaginis Herba. Conclusion: Content of verbascoside in Plantaginis Semen was higher than that of Plantaginis Herba

while the content of isoverbascoside was below than that of Plantaginis Herba. The content differences shall be seriously considered in clinical application. It is recommended to add isoverbascoside as a mark component for the quality control of Plantaginis Semen and Plantaginis Herba.

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