ZHANG Yue, QU Ye-qing, CHEN Jun, et al. Investigation of Release Properties of Ferulic Acid Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(19): 1-5.
DOI:
ZHANG Yue, QU Ye-qing, CHEN Jun, et al. Investigation of Release Properties of Ferulic Acid Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(19): 1-5. DOI: 10.13422/j.cnki.syfjx.2016190001.
Investigation of Release Properties of Ferulic Acid Liposomes
Objective: To obtain sustained-release preparations of ferulic acid liposomes by optimizing its formulation and technology. Method: The content of ferulic acid in liposomes was determined by HPLC.Ferulic acid was encapsulated into liposomes by calcium acetate gradient method
dialysis method was used to investigate release of ferulic acid.The factors such as phospholipids
the content of cholesterol
particle size and the addition of blood components were intensively investigated.Moreover
thermosensitive hydrogel technique was further applied to obtain the satisfactory sustained-release effect. Result: Hydrogenated soybean phosphatidylcholine (HSPC) was selected as the phospholipid composition. Optimum molar ratio between HSPC and cholesterol was determined at 4:1.Optimum average size of liposomes was found to be 397.7 nm.Blood components could accelerate the release of ferulic acid liposomes and there was little difference among different blood (human serum
fetal calf serum and rat plasma).Moreover
with the application of thermosensitive hydrogel technique
sustained-release effect was obtained in 48 h and the kinetics was fitted with Higuchi equation. Conclusion: Fetal calf serum and rat plasma can be used in drug release studies of liposomes to mimic human serum.Optimization of formulation and technique factors as well as the combined application of thermosensitive hydrogel technique can result in the satisfactory sustained-release properties of ferulic acid liposomes.
Combination of Components from Tripterygii Radix et Rhizoma-Chuanxiong Rhizoma Affects RA-FLSs by Regulating NF-κB, Nrf2/HO-1 Signaling Pathways and Bcl-2/Caspase-3 Expression
Pharmacodynamic Effect and Mechanism of Xiaoke Drink in Ameliorating Insulin Resistance in ob/ob Mice
Cloning and Expression Patterns of Coumarate-3-hydroxylase Gene from Angelica sinensis and Its Correlation with Content of Ferulic Acid
In vivo Fate of Functionalized Liposomes:Applications and Challenges
Chronic Toxicity of Triptolide and Ferulic Acid Ethosomes Gel for Percutaneous Administration
Related Author
GUAN Yongmei
WAN Zhiyan
WANG Shuhui
ZHU Weifeng
LIU Zhiyong
JIANG Cheng
ZANG Zhenzhong
ZHAO Baosheng
Related Institution
Laboratory Animal Science and Technology Center,Jiangxi University of Chinese Medicine
National Key Laboratory of Modern Chinese Medicine Creation of Classic Prescriptions
Jiangxi University of Chinese Medicine,Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine