Objective: To investigate the efficacy of Xiaozheng Yin for the pain in endometriosis (EMS) with Qi stagnation and blood stasis and observe its effects on levels of matrix metalloproteinase (MMP)-3

MMP-9

vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α). Method: One hundred and eight patients were randomly divided into control group (53 cases) and observation group (55 cases). Patients in both groups took Gestrinone capsules

2.5 mg/time

2 times/week

continuing for six months. Patients in control group also took Sanjie Zhentong capsule

4 pieces/time

3 times/day

while patients in observation group orally took Xiaozheng Yin

1 dose/day. Both groups took drugs 28 days a month

continuing for 6 months. Medicines were not withdrawn in menstrual cycle period. The levels of serum cancer antigen 125(CA125) and CA199

levels of serum MMP-3

MMP-9

VEGF and TNF-α were detected before and after treatment. Scores of pain

symptoms and endometriosis health profile-5 (EHP-5) were graded before and after treatment. Result: After therapy

scores of visual analogue scale (VAS)

dysmenorrhea

pelvic pain

pelvic tenderness

and sacral ligament tenderness nodules in observation group were significantly lower than those in control group (P<0.01). After treatment

levels of CA125 and CA199 in observation group were lower than those in control group (P<0.05)

levels of serum MMP-3

MMP-9

VEGF and TNF-α in observation group were less than those in control group (P<0.05

P<0.01)

the scores of pain

emotional state

control

sexual life

infertility and treatment effects at EHP-5 in observation group were significantly lower than those in control group (P<0.01). The total effective rate in treatment group was superior to that in control group (P<0.05). Conclusion: Xiaozheng Yin can obviously improve pain for EMS patients

enhance their quality of life

reduce levels of serum CA125

CA199

MMP-3

MMP-9

VEGF and TNF-α. Therefore

it can promote disease recovery.