Objective: To discuss the effects of Dizhuo Huatan decoction on lung function and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with syndrome of phlegm and blood stasis obstructing lung

and investigate its action mechanism. Method: One hundred and fifty-six patients were randomly divided into control group and observation group. Patients in control group took controlled oxygen therapy

anti-infection

hormone

bronchodilators

ipratropium bromide aerosol

4 times/day

2 sprays/time

cefminox sodium for injection

2 g/time

2 times/day

acetylcysteine granules

0.4 g/time

3 times/day. Based on the treatment of control group

patients in observation group also received Dizhuo Huatan decoction

1 dose/day. The treatment course was 2 weeks for both groups. Before and after treatment

lung function was detected

forced vital capacity rate of one second (FEV/FVC) and forced expiratory volume in 1 second (FEV1%) were recorded. Blood oxygen pressure (PaO2)

partial pressure of carbon dioxide (PaCO2) and oxygen saturation were detected before and after treatment. Scores of syndrome of phlegm and blood stasis obstructing lung and difficulty in breathing severity were evaluated by Modified the medical research council respiratory questionnaire (mMRC) and COPD patients self assessment test (CAT) before and after treatment. The levels of nuclear factor-κB (NF-κB)

serum interleukin-10 (IL-10)

tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) were detected. Result: The total clinical effect rate in observation group was higher than that in control group (P<0.05). Pulmonary function grading of airflow limitation severity in observation group was lower than that in control group (P<0.05). Scores of syndrome of phlegm and blood stasis obstructing lung

mMRC and CAT in observation group were lower than those in control group (P<0.01). FEV1 and FEV1/FVC in observation group were higher than those in control group after treatment (P<0.01). PaCO2 in observation group was lower than that in control group

and levels of PaO2 and SaO2were higher than those in control group after treatment (P<0.01). Levels of NF-κB

TNF-α and hs-CRP in observation group were lower than those in control group

while the level of IL-10 was higher than that in control group after treatment (P<0.01). Conclusion: Based on the treatment of routine western medicine

Dizhuo Huatan decoction can ameliorate symptoms and lung function and relieve inflammatory response when it is used for AECOPD with syndrome of phlegm and blood stasis obstructing lung.