Objective: To discuss the clinical efficacy of modified treatment of Shaoyao Tang retention enema combined with mesalazine in treating large intestine damp-heat type ulcerative colitis(UC)

and investigate its effects on immuno-inflammatory responses. Method: One hundred and sixty UC patients were randomly divided into control group(80 cases) and observation group(80 cases) by random number table. Patients in control group took mesalazine enteric-coated tablets by swallowwing

1 g/time

4 times/day

hydrocortisone sodium succinate for enema

100-200 mg. Patients in observation group took modified treatment of Shaoyao Tang retention enema combined with mesalazine. For both groups

enema was retained for 5 days a week and 2 days for rest

with continuous treatment courses of 8 weeks. Before and after treatment

scores of Sutherland disease activity index

Baron scores

Geboes indexes and large intestine damp-heat syndrome scores were graded. Patients' quality of life were evaluated by IBDQ scale. Levels of tumor necrosis factor-α(TNF-α)

interleukin-4(IL-4)

interleukin-1β(IL-1β)

interleukin-10(IL-10)

transforming growth factor(TGF-β)

and matrix metalloproteinase-1(MMP-1) were detected before and after treatment. Result: The total effect rate of comprehensive efficacy was 90%in observation group

higher than 76.25%in control group

with statistically significant difference between two groups(P<0.05). The total effect rate of TCM syndrome was 92.5%in observation group

higher than 75%in control group

with statistically significant difference between two groups(P<0.01). After treatment

the scores of Sutherland disease activity index

Baron scores

Geboes indexes and large intestine damp-heat syndrome scores in observation group were all lower than those in control group(P<0.01). The individual scores and total scores of intestinal symptoms

general symptoms

emotional capability and social competence in IBDQ scale of observation group were higher than those in control group(P<0.01). Levels of serum IL-1β

TNF-α and MMP-1 were lower than those in control group

and levels of IL-4

IL-10 and TGF-β were higher than those in control group(P<0.01). Conclusion: Modified treatment of Shaoyao Tang retention enema combined with mesalazine can improve clinical symptoms

patients' quality of life and healing quality of intestinal mucosa

and regulate immuno-inflammatory responses in treatment of UC with large intestine damp-heat at active stage.