Objective: To discuss the clinical effect of Tongluo Qingkong decoction in treating migraine within the acute attack period based on differentiation and its influence on serum levels of 5-hydroxytryptamine (5-HT)

substance P (SP)

endothelin (ET)

homocysteine (Hcy) and nitric oxide (NO). Method: One hundred and twenty-one eligible patients were randomly divided into observation group (60 cases) and control group (61 cases) by number tablet. Control group took Changchun sustained release capsules and Ibuprofen tablets. In addition to the therapy of control group

patients in observation group were additionally administered with modified Tongluo Qingkong decoction based on differentiation. Courses of treatment in two groups continued for 4 weeks. Immediate analgesic effect was valuated

and migraine disability assessment questionnaire (MIDAS) was adopted to evaluate quality of life. Main symptoms

such as degree of headache

onset frequency

duration and symptoms

were scored. Levels of 5-HT

SP

ET

NO and Hcy were detected. Result: The effect rate of immediate curative effect in observation group was 83.33%

which was superior to 63.93%in control group (P<0.05). After treatment

the effect rate of short-term clinical effect in observation group was 93.33%

which was superior to 80.33%in control group (P<0.05). At the 2

3

5 and 7 h after treatment

score of VAS in observation group was lower than that in control group (P<0.01 or P<0.05). And after treatment

scores of MIDAS and main symptoms in observation group were lower than those in control group (P<0.01). Compared with the healthy control group

the lovels of 5-HT in the two groups before treatment were significantly decreased

and levels of SP

ET

NO and Hcy were higher than those in healthy control group (P<0.01). And level of 5-HT in observation group was higher than that in control group (P<0.01). Levels of SP

ET

NO and Hcy were lower than those in control group (P<0.01). Conclusion: In addition to the medicine western routine therapy

Tongluo Qingkong decoction based on differentiation can be adopted to relieve pain quickly

reduce frequency of pain attack

improve qualities of live within the acute attack period

with superior immediate curative effect and short-term effect to the pure western medicine therapy. Its action mechanism may be correlated with the regulation of nerve-endocrine factors and vascular endothelial functions.