Objective: To optimize prescription and preparation technology of shortstalk monkshood root total alkaloids microemulsion gel

and investigation of its quality and stability. Method: Shortstalk monkshood root total alkaloids microemulsion was prepared

then shortstalk monkshood root total alkaloids microemulsion gel was prepared by gel matrix addition

the concentration of index components and pH value were evaluated

its stability was investigated by centrifugation test

cold and heat test.HPLC was adopted to determine the content of bullatine A with mobile phase consisted of acetonitrile-phosphate buffer with pH of 7.3 (18:82) and detection wavelength at 199 nm. Result: Shortstalk monkshood root total alkaloids microemulsion gel (100 g) were consisted of 86 g of microemulsion

4 g of Xanthan gum and 10 g of glycerin.Its average particle size was 18.72 nm and polydispersity index was 0.663 with pH of 6.4.There was no stratification after centrifugation

and after storaged at -4℃ and 40℃ conditions for 24 h

there were no significant difference in appearance

character

ductility by comparing with before.The content of bullatine A was 1.79 mg·g-1. Conclusion: The preparation process of shortstalk monkshood root total alkaloids microemulsion gel is simple

which is in line with requirements of gel topical preparation.