Comparison on Pharmacodynamic Differences Between Xiao'er Baibu Zhike Tangjiang with Raw or Processed Products of Stemonae Radix

CHEN Xiao-xia; ZHANG Xu; JIA Tian-zhu

doi:10.13422/j.cnki.syfjx.2016210023

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Comparison on Pharmacodynamic Differences Between Xiao'er Baibu Zhike Tangjiang with Raw or Processed Products of Stemonae Radix

更新时间：2024-01-04

- Comparison on Pharmacodynamic Differences Between Xiao'er Baibu Zhike Tangjiang with Raw or Processed Products of Stemonae Radix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 21, Pages: 23-26(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016210023
  CLC： R285.5
- Published：2016
- 稿件说明：
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CHEN Xiao-xia, ZHANG Xu, JIA Tian-zhu. Comparison on Pharmacodynamic Differences Between Xiao'er Baibu Zhike Tangjiang with Raw or Processed Products of Stemonae Radix[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(21): 23-26.
DOI：

CHEN Xiao-xia, ZHANG Xu, JIA Tian-zhu. Comparison on Pharmacodynamic Differences Between Xiao'er Baibu Zhike Tangjiang with Raw or Processed Products of Stemonae Radix[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(21): 23-26. DOI： 10.13422/j.cnki.syfjx.2016210023.

摘要

目的：探讨百部生品、蜜炙品分别入小儿百部止咳糖浆复方后止咳活性及其治疗小鼠肺炎作用的差异。方法：采用柠檬酸豚鼠引咳模型，研究不同剂量生百部复方、蜜炙百部复方的止咳差异。以脂多糖刺激小鼠肺炎模型及合胞病毒小鼠肺炎模型，研究分别口服给予生百部复方、蜜炙百部复方后小鼠肺泡灌洗液中白细胞介素-4（IL-4），IL-10，γ干扰素（IFN-γ）和肿瘤坏死因子-α（TNF-α）的含量变化，并对其肺组织进行病理切片比较。结果：与同剂量生百部复方组相比，蜜炙百部复方中、高剂量组止咳作用显著增强；与生百部复方高剂量组比较，蜜炙百部复方高剂量组肺炎模型中肺组织炎症细胞浸润显著降低，IFN-γ/IL-4显著回调。结论：临床使用百部止咳及治疗呼吸道疾病时建议以蜜炙百部入药，以更好地发挥疗效。

Abstract

Objective: To investigate difference of antitussive activity and treatment of pneumonia in mice between Xiao'er Baibu Zhike Tangjiang with raw or processed products of Stemonae Radix. Method: Cough model of guinea pigs induced by citric acid was established to investigate antitussive difference between raw products compound and processed products compound with different doses.Lipopolysaccharide was adopted to stimulate mice pneumonia model and syncytial virus mouse pneumonia model

raw products compound and processed products compound were orally asministrated

concentration of tumor necrosis factor-α (TNF-α)

interleukin-10 (IL-10)

γ-interferon (IFN-γ) and IL-4 in rats bronchoalveolar lavage fluid were detected

lung tissues were sliced. Result: Compared with the same dose of raw products compound

middle and high dose of processed products compound showed distinctly stronger antitussive activity;compared with the high dose of raw products compound

high dose of processed products compound showed lower inflammatory cell infiltration and more regressive ratio of IFN-γ/IL-4. Conclusion: In order to play a better therapeutic effect

honey-processed Stemonae Radix should be used to prepare Xiao'er Baibu Zhike Tangjiang.

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