Influence of Processing on Contents and Dissolution Rates of Hypaphorine and Flavonoid Glycosides in Vaccariae Semen

ZHOU Guo-hong; TANG Li-ying; KOU Zhen-zhen; WANG Ting; GUO Ri-xin; WANG Zhu-ju

doi:10.13422/j.cnki.syfjx.2016220018

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Influence of Processing on Contents and Dissolution Rates of Hypaphorine and Flavonoid Glycosides in Vaccariae Semen

更新时间：2024-01-04

- Influence of Processing on Contents and Dissolution Rates of Hypaphorine and Flavonoid Glycosides in Vaccariae Semen
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 22, Pages: 18-21(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016220018
  CLC： R283.1
- Published：2016
- 稿件说明：
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ZHOU Guo-hong, TANG Li-ying, KOU Zhen-zhen, et al. Influence of Processing on Contents and Dissolution Rates of Hypaphorine and Flavonoid Glycosides in Vaccariae Semen[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(22): 18-21.
DOI：

ZHOU Guo-hong, TANG Li-ying, KOU Zhen-zhen, et al. Influence of Processing on Contents and Dissolution Rates of Hypaphorine and Flavonoid Glycosides in Vaccariae Semen[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(22): 18-21. DOI： 10.13422/j.cnki.syfjx.2016220018.

摘要

目的：研究炮制对王不留行中刺桐碱及黄酮苷类成分含量的影响，探索炮制对王不留行主要化学成分及其溶出率的影响。方法：采用HPLC测定炮制前后王不留行中刺桐碱、王不留行黄酮苷、肥皂草苷、异牡荆素-2”-O-阿拉伯糖苷和王不留行黄酮苷H的含量及水煎溶出率，流动相乙腈（A）-水（B）梯度洗脱（0~12 min，13% A；12~18 min，17% A；18~30 min，20% A），检测波长280 nm。结果：炮制前，这5个成分的质量分数分别为0.13%，0.70%，0.018%，0.051%，0.11%，炮制后则分别为0.12%，0.52%，0.016%，0.098%，0.091%；5个成分的水煎溶出率分别升高了7.7%，10.2%，10.8%，11.4%，17.8%。结论：炮制后异牡荆素-2”-O-阿拉伯糖苷含量有较大幅度上升，而王不留行黄酮苷含量有较大下降，其余成分含量有少量下降。炮制对王不留行中刺桐碱及黄酮苷类成分含量的影响存在一定差异，但炮制后这些成分的水煎溶出率均上升。

Abstract

Objective: To investigate the influence of processing on contents of hypaphorine and flavonoid glycosides in Vaccariae Semen. Method: Before and after processing

HPLC was employed to determined contents and dissolution rates of hypaphorine

vaccarin

saponarin

isovitexin-2"-O-arabinoside and vaccarin H in Vaccariae Semen with the mobile phase of acetonitrile-water for gradient elution and detection wavelength at 280 nm. Result: Before processing

their contents were 0.13%

0.70%

0.018%

0.051%and 0.11%;after processing

their contents were 0.12%

0.52%

0.016%

0.098%and 0.091%

respectively.However

dissolution rates of these five ingredients were raised by 7.7%

10.2%

10.8%

11.4%and 17.8%

respectively. Conclusion: Processing has different influence on contents of hypaphorine and flavonoid glycosides in Vaccariae Semen

but their dissolution rates raise.

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