Objective: To optimize alcohol and water extraction processes of Pingtang compound. Method: Taking extraction time

the amount and concentration of ethanol as factors

orthogonal test was adopted to optimize alcohol extraction process with composite score of dry extract yield

transfer rates of ligustilide

cinnamic aldehyde and methyl eugenol as index.Taking soaking time

the amount of water and extraction time as factors

orthogonal test was adopted to optimize water extraction process with composite score of dry extract yield

transfer rates of puerarin and ferulic acid as index. Result: Optimum alcohol extraction conditions of Angelicae Sinensis Radix

Cinnamomi Ramulus

Asari Radix et Rhizoma was reflux extracting twice with 8 and 6 times of 50% ethanol for 0.5 h of each time.Transfer rates of ligustilide

cinnamic aldehyde

methyl eugenol and dry extract yield was 72.8%

70.5%

82.3%

27.8%

respectively.Optimal water extraction process for residue after alcohol extraction with Puerariae Lobatae Radix was soaking 30 min and decocting thrice with 12 times of water for 0.5 h of each time.Transfer rates of puerarin and ferulic acid was 60.28% and 21.89%

dry extract yield was 18.43%. Conclusion: These optimized extraction processes are stable and reproducible with high extracting rates of active ingredients in Pingtang compound.