Schisandrae Chinensis Fructus Polysaccharide Protects Against Chemotherapy-Induced Enteritis in Mice Models

ZHOU Wei-dong; XIANG Lei; CHEN Ze-wei; LU Han-qi; LUO Ren; SUN Xiao-min; ZHAO Xiao-shan; TAN Wei

doi:10.13422/j.cnki.syfjx.2016220124

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Schisandrae Chinensis Fructus Polysaccharide Protects Against Chemotherapy-Induced Enteritis in Mice Models

更新时间：2024-01-04

- Schisandrae Chinensis Fructus Polysaccharide Protects Against Chemotherapy-Induced Enteritis in Mice Models
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 22, Pages: 124-128(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016220124
  CLC： R285.5
- Published：2016
- 稿件说明：
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ZHOU Wei-dong, XIANG Lei, CHEN Ze-wei, et al. Schisandrae Chinensis Fructus Polysaccharide Protects Against Chemotherapy-Induced Enteritis in Mice Models[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(22): 124-128.
DOI：

ZHOU Wei-dong, XIANG Lei, CHEN Ze-wei, et al. Schisandrae Chinensis Fructus Polysaccharide Protects Against Chemotherapy-Induced Enteritis in Mice Models[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(22): 124-128. DOI： 10.13422/j.cnki.syfjx.2016220124.

摘要

目的：观察五味子多糖对5-氟尿嘧啶（5-FU）引起的肠道黏膜炎的治疗作用及探讨其作用机制。方法：使用5-FU造模，将小鼠随机分为正常组，模型组，多糖高、中、低剂量组（20，10，5 mg·kg-1）。观测小鼠腹泻和体重情况；将小鼠处死后，通过测量小肠绒毛高度、隐窝深度、以及计算绒毛高度/隐窝深度比值进行形态学评价；通过酶联免疫（ELISA）法测定小肠组织白细胞介素-1β（IL-1β），IL-6，肿瘤坏死因子-α（TNF-α）的含量。结果：给药第4天，与模型组相比，高、中剂量多糖组体重比率明显提高（P<0.01）；高、中剂量多糖组大便得分显著低于模型组（P<0.05，P<0.01）。五味子多糖显著抑制5-FU引起的小肠肠绒毛高度缩短、隐窝深度值更大、绒毛高度/隐窝深度比减少（P<0.01）；明显降低TNF-α，IL-1β，IL6水平（P<0.01）。结论：五味子多糖能改善5-FU引起的肠道黏膜炎症状，其作用机制可能与通过抑制TNF-α，IL-1β，IL6等炎症因子的水平有关。

Abstract

Objective: To observe the therapeutic effect of Schisandrae Chinensis Fructus polysaccharide (SCFP) on 5-fluorouracil (5-FU) induced gastrointestinal mucositis and explore the underlying mechanism. Method: 5-FU was used to establish models and the mice were randomly divided into normal group

control group

low-dose polysaccharide (LDP) group

middle-dose polysaccharide (MDP) group and high-dose polysaccharide (HDP) group (5

and 20 mg·kg-1 respectively). Body weight and scoring for diarrhoea index were recorded. After the mice were sacrificed

small intestinal villous height and crypt depth were measured for orphological evaluation; the levels of tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)

interleukin-1β (IL-1β) in the intestinal tissues were determined by ELISA. Result: On day 4 of treatment

as compared with the control group

the body weight loss in MDP group and HDP group was inhabited significantly (P<0.01); diarrhoea scores of mice in MDP group and HDP group were significantly decreased (P<0.05

P<0.01). SCFP significantly inhibited the shortening of villus heights

enlarging of crypts depths and redecreasing of villus heights/crypts depths ratio in small intestine induced by 5-Fu (P<0.01). The levels of TNF-α

IL-1β

and IL-6 in mice treated with SCFP were significantly decreased in comparison with the normal group (P<0.01). Conclusion: Our results suggest that SCFP could improve the symptoms of gastrointestinal mucositis induced by 5-FU

and the mechanism may beassociated with inhibiting the levels of TNF-α

IL-6 and IL-1β.

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