Effect of Fillers on Rheological Characterization of Gel Plaster Matrix

WANG Jian; LI Wei; TIAN Jing-zhen; SHEN Teng

doi:10.13422/j.cnki.syfjx.2016230024

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Effect of Fillers on Rheological Characterization of Gel Plaster Matrix

更新时间：2024-01-04

- Effect of Fillers on Rheological Characterization of Gel Plaster Matrix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 23, Pages: 24-27(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016230024
  CLC： R283.6
- Published：2016
- 稿件说明：
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WANG Jian, LI Wei, TIAN Jing-zhen, et al. Effect of Fillers on Rheological Characterization of Gel Plaster Matrix[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 24-27.
DOI：

WANG Jian, LI Wei, TIAN Jing-zhen, et al. Effect of Fillers on Rheological Characterization of Gel Plaster Matrix[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 24-27. DOI： 10.13422/j.cnki.syfjx.2016230024.

摘要

目的：粘弹性是凝胶贴膏基质的一个基本性质，粘弹性可通过测量凝胶贴膏的流变特性来确定。通过研究不同填充剂对凝胶贴膏基质的流变学特性的影响，为筛选基质处方提供参考。方法：利用旋转流变仪测定不同填充剂基质配方的流变学性质，包括复数模量（G*），弹性模量（G'）和粘性模量（G″），研究不同填充剂对基质流变学特性的影响，同时对比不同填充剂基质的黏附性，建立用流变学筛选填充剂基质的方法。结果：不同填充剂随着质量分数的增加，G'和G″均增加，尤其是微粉硅胶，其质量分数由1%增加到5%时，G'和G″分别增加了99%和130%。结论：凝胶贴膏基质的流变学可为凝胶贴膏处方的筛选提供借鉴。

Abstract

Objective: Viscoelasticity is one of the fundamental properties of gel plaster matrix

it can be determined by measuring the rheological properties of gel plaster matrix.To investigate effects of various fillers on the rheological characteristics of gel plaster matrix. Method: Rotary rheometer was employed to determine rheological properties of matrix containing various fillers

including the complex modulus (G*)

the elastic modulus (G') and the viscous modulus (G″).The influence of fillers on rheological properties of matrix was investigated

the adhesion performances of matrix were considered

and a method for screening fillers with the rheological properties of matrix was established. Result: Both of G' and G″ increased with increasing of fillers concent

especially for micropowder silica gel.When the concent of micropowder silica gel increased from 1% to 5%

G' and G″ increased 99% and 130%

respectively. Conclusion: Rheological properties of gel plaster matrix can serve as guidelines for optimization of formulations of gel plaster.

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Related Institution

School of Chinese Materia Medica, Beijing University of Chinese Medicine

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