Chemical Constituents from Roots of

SUN Wen-ting; CAI You-sheng; YANG Sheng-ping

doi:10.13422/j.cnki.syfjx.2016230049

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Chemical Constituents from Roots of

更新时间：2024-01-04

- Chemical Constituents from Roots of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 23, Pages: 49-54(2016)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2016230049
  CLC： R284.1
- Published：2016
- 稿件说明：
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SUN Wen-ting, CAI You-sheng, YANG Sheng-ping. Chemical Constituents from Roots of [J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 49-54.
DOI：

SUN Wen-ting, CAI You-sheng, YANG Sheng-ping. Chemical Constituents from Roots of [J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 49-54. DOI： 10.13422/j.cnki.syfjx.2016230049.

摘要

目的：研究芫花Daphne genkwa根的化学成分，并筛选其生物活性。方法：采用硅胶柱色谱，凝胶柱色谱等手段，结合理化性质和波谱数据，对芫花根的乙酸乙酯萃取部分的化合物进行分离鉴定。结果：从芫花根中分离得到了16个化合物，分别鉴定为二氢瑞香素乙（dihydrodaphnodorin B，1），荛花醇A（wikstrol A，2），瑞香酚（stelleranol，3），毛瑞香素D2（daphnodorin D2，4），毛瑞香素D1（daphnodorin D1，5），毛瑞香素A（daphnodorin A，6），O-methyledgeworin（7），clemaphenol A（8），1β-hydroxy-10βH-guaia-4，11-dien-3-one（9），1αH，10αH，7αH-guaia-4，11-dien-3-one（10），1，5-diphenylpentan-1-hydroxy-3-one（11），oleodaphnone（12），S-（+）-1，5-diphenylpentan-3-hydroxy-1-one（13），8-hydroxypluviatolide（14），表木栓醇（epifriedelanol，15），5α-stigmast-9（11）-en-3β-ol（16）。生物活性筛选结果表明，化合物1，2，6对金黄色葡萄球菌有抑制作用。结论：化合物1~6，10，12，13首次从芫花中分离得到，化合物11，15首次从瑞香属中分离得到，化合物7~9，14，16首次从瑞香科中分离得到。

Abstract

Objective: To study the chemical constituents in the roots of Daphne genkwa

and screen their biological activity. Method: The compounds were isolated by silica gel column chromatography

Sephandex LH-20

and their structures were elucidated by means of spectral analysis. Result: Sixteen compounds were isolated and identified as dihydrodaphnodorin B (1)

wikstrol A (2)

stelleranol (3)

daphnodorin D2 (4)

daphnodorin D1 (5)

daphnodorin A (6)

O-methyledgeworin (7)

clemaphenol A (8)

1β-hydroxy-10βH-guaia-4

11-dien-3-one (9)

1αH

10αH

7αH-guaia-4

11-dien-3-one (10)

5-diphenylpentan-1-hydroxy-3-one (11)

oleodaphnone (12)

S-(+)-1

5-diphenylpentan-3-hydroxy-1-one (13)

8-hydroxypluviatolide (14)

epifriedelanol (15)

and 5α-stigmast-9(11)-en-3β-ol (16). The screening results of biological activity showed that compounds 1

6 had inhibitory effect on Staphylococcus aureus. Conclusion: Compounds 1-6

13 were isolated from this plant for the first time. Compounds 11

15 were isolated from the plants of this genus for the first time. Compounds 7-9

16 were first obtained from the plants of Thymelaeaceae.

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