Chemical Constituents of

HUANG Mao-xin; CAI Yang-jing; WANG Jun; WANG Wei; CHEN Ling; HAN Peng-ding; LIU Shou-bai

doi:10.13422/j.cnki.syfjx.2016230055

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Chemical Constituents of

更新时间：2024-01-04

- Chemical Constituents of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 23, Pages: 55-59(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016230055
  CLC： R284.1
- Published：2016
- 稿件说明：
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HUANG Mao-xin, CAI Yang-jing, WANG Jun, et al. Chemical Constituents of [J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 55-59.
DOI：

HUANG Mao-xin, CAI Yang-jing, WANG Jun, et al. Chemical Constituents of [J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 55-59. DOI： 10.13422/j.cnki.syfjx.2016230055.

摘要

目的：研究忧遁草Clinacanthus nutans枝叶乙酸乙酯部位的化学成分。方法：采用反复硅胶柱色谱法，Sephadex LH-20柱色谱法，MCI柱色谱法等分离纯化手段相结合对忧遁草进行分离纯化，并通过波谱数据（1H-NMR，13 C-NMR）鉴定其化学结构。结果：从忧遁草枝叶中分离鉴定了10个化合物，分别鉴定为吲唑（1），loliolide（2），（3S，5R，6S，7E）-5，6-环氧-3-羟基-7-大柱香波龙烯-9-酮（3），植醇（4），（-）-α-tocospirone（5），α-nigerose（6），clerspide A（7），（2R）-1-O-glyceryl-β-D-galactoside（8），豆甾醇（9），胡萝卜苷（10）。结论：化合物2~8为首次从忧遁草枝叶中分离得到，为阐明忧遁草的药效物质基础提供了有力证据，为海南产的忧遁草资源的开发利用提供了科学依据。

Abstract

Objective: To study on chemical constituents from the ethyl acetate extraction of the twigs and leaves of Clinacanthus nutans. Method: The compounds were isolated by chromatographic techniques

such as silica gel and Sephadex LH-20.The structures of these compounds were identified on the basis of organic spetra (1H-NMR

13 C-NMR). Result: Ten compounds were isolated from C.nutans and identified asindazole(1)

loliolide (2)

(3S

7E)-5

6-epoxy-3-hydroxy-7-megastigmen-9-one (3)

phytol (4)

(-)-α-tocospirone (5)

α-nigerose (6)

clerspide A (7)

(2R)-1-O-glyceryl-β-D-galactoside(8)

stigmasterol (9)

daucosterol (10)

respectively. Conclusion: The compounds 2-8 were obtained from the twigs and leaves of C.nutans for the first time. This research could provide powerful therapeutic material basis for C.nutans and provide a scientific basis for further research and development on the resourse of C.nutans in Hainan.

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Related Institution

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