Objective: To observe the clinical efficacy of Qingyi decoction with naso-jejunal instillation therapy in treating moderate acute pancreatitis (MSAP) and investigate its effects on inflammatory factors and intestinal mucosal barrier function. Method: One hundred and fifty patients with MSAP were randomly divided into control group (75 cases) and observation group (75 cases) by random number table. Basic treatment

Esomeprazole sodium injection

40 mg

intravenous injection

1 time/12 hours

ulinastatin injection

300 thousand units

continuous venous pump

1 time/12 hours

meropenem injection

1 g/time

with slow venous pump for 4 hours

1 time/8 hours. Patients in both groups received Qingyi decoction

1 dose/day. It was injected in 2-3 times by conventional gastric tube in control group

while in observation group

it was used by naso-jejunal instillation method

100-150 mL/time

at 50-100 mL·h-1

4-6 times/day. The treatment course was 10 days for both groups. Time of bellyache

abdominal distension

recovery of bowel sound and ventilation defecation were recorded. Before and after treatment

the blood routine examination

amylase in blood and urine

blood glucose and blood calcium were monitored. Levels of interleukin-1 (IL-1)

interleukin-6 (IL-6)

and tumor necrosis factor-α (TNF-α) in serum were detected both before and after treatment

and the levels of D-lactic acid

endotoxin and urinary lactulose/mannitol (L/M) in plasma were detected both before and after treatment. Result: The clinical efficacy in observation group was superior to that in control group (P<0.05) by Ridit analysis. After treatment

the enteroplegia related indexes (time of bellyache

abdominal distension

recovery of bowel sound and ventilation defecation) in observation group were lower than those in control group (P<0.01). After treatment

the levels of leukocyte

amylase in blood and urine

and fasting blood-glucose in observation group were lower than those in control group (P<0.01)

and the level of serum calcium was higher than that in control group (P<0.01). Levels of IL-1

IL-6 and TNF-α in observation group were lower than those in control group after treatment (P<0.01)

levels of D-lactic acid and urinary lactulose/mannitol (L/M) in observation group were also lower than those in control group (P<0.01). Conclusion: Qingyi decoction with naso-jejunal instillation therapy combined with conventional western medicine can more effectively improve the enteroplegia indexes

promote the recovery of gastrointestinal function

relieve inflammatory reaction

and promote intestinal mucosal barrier function in treating moderate acute pancreatitis.