Objective: To optimize the formulation of self-microemulsion containing total flavonoids from Folium Kaki by simplex lattice method. Method: Based on screening of preparation process

taking rates of oil phase

emulsifier and co-emulsifier as factors

simplex lattice method was adopted to optimize formulation with particle size

polydispersity index and drug loading as indexes.Physicochemical properties of this self-microemulsion were determined

such as viscosity

dissolution and so on. Result: Optimum formulation was 10% of median chain triglyceride oil

30% of polyoxyethylene hydrogenated castor oil

60% of diethylene glycol ethyl ether.Average particle size

polydispersity index and drug loading of self-microemulsion containing total flavonoids from Folium Kaki were 32.7 nm

0.163 and 22.42 mg·g-1;physicochemical properties was stable

cumulative dissolution at 20 min was 89.09%. Conclusion: Simplex lattice method can build a mathematical models with good prediction and objective analysis

and it can provide a new idea for optimization of self-croemusion formulation.