Selection of Best Semi-bionic Extracting Mode of Zhizi Bopi Tang

YU Ding-rong; JING Han-wei

doi:10.13422/j.cnki.syfjx.2016240022

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Selection of Best Semi-bionic Extracting Mode of Zhizi Bopi Tang

更新时间：2024-01-04

- Selection of Best Semi-bionic Extracting Mode of Zhizi Bopi Tang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 24, Pages: 22-25(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016240022
  CLC： R283.6
- Published：2016
- 稿件说明：
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YU Ding-rong, JING Han-wei. Selection of Best Semi-bionic Extracting Mode of Zhizi Bopi Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(24): 22-25.
DOI：

YU Ding-rong, JING Han-wei. Selection of Best Semi-bionic Extracting Mode of Zhizi Bopi Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(24): 22-25. DOI： 10.13422/j.cnki.syfjx.2016240022.

摘要

目的：优选栀子柏皮汤半仿生提取药材组合方式，为栀子柏皮汤提取工艺提供依据。方法：将方中方药按“君（A），臣（B），佐（C），使（D）”进行组合排列，共5种，用半仿生提取方法进行提取；以相对分子质量≤1 000 Da提取物、栀子苷、盐酸小檗碱、甘草次酸、总生物碱为指标，将各指标测得值标准化处理，经加权求和后得到综合评判值进行比较，大者为优。结果： 5个指标综合评判值排序依次为B+AC >A+B+C >C+AB >ABC >A+BC，以B+AC（关黄柏单煎，栀子、甘草合煎）最大。结论：栀子柏皮汤半仿生提取方法以关黄柏单煎，栀子、甘草合煎，最后合并提取液为最佳。

Abstract

Objective: To select the best semi-bionic extraction method of Zhizi Bopi Tang

and provide the scientific basis for extracting process of Zhizi Bopi decoction. Method: The herbs in the prescription were arranged in different combinations based on ‘Jun(A)

Chen(B)

Zuo(C) and Shi(D)’ principle. There were 5 combinations in total

and semi-bionic extraction method was used for extraction. The levels of gardenoside

berberine hydrochloride

glycyrrhetinic acid

total alkaloids and extracts with molecular weight≤1 000 Da were used as the indexes. The comprehensive evaluation values were acquired by using weighted summation of the five indexes after standardized treatment. Those with larger comprehensive evaluation values were better than others. Result: The comprehensive evaluation value Y was B+AC >A+B+C >C+AB >ABC >A+BC respectively for the 5 indexes

and B+AC was the biggest value. Conclusion: The semi-bionic extraction method of Zhizi Bopi Tang is decocting Cortex Phellodendri Chinensis solely first

then decocting Gardeniae Fructus and Glycyrrhizae Radix together

and finally combining the above extract Tang.

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