Molecular Level Studies on Drug and Cell Membrane Interactions Using Nonlinear Optical Spectroscopy

CHEN Zhan

doi:10.13422/j.cnki.syfjx.2017010012

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Molecular Level Studies on Drug and Cell Membrane Interactions Using Nonlinear Optical Spectroscopy

更新时间：2024-01-04

- Molecular Level Studies on Drug and Cell Membrane Interactions Using Nonlinear Optical Spectroscopy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 1, Pages: 12-19(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017010012
  CLC： R96;O657.3
- Published：2017
- 稿件说明：
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CHEN Zhan. Molecular Level Studies on Drug and Cell Membrane Interactions Using Nonlinear Optical Spectroscopy[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 12-19.
DOI：

CHEN Zhan. Molecular Level Studies on Drug and Cell Membrane Interactions Using Nonlinear Optical Spectroscopy[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 12-19. DOI： 10.13422/j.cnki.syfjx.2017010012.

摘要

本文阐明不同药物与细胞膜原位作用的分子机制。应用一种非线性光谱-和频振动光谱来研究抗菌药物分子以及氯丙嗪、金刚烷胺和美金刚与电中性和电负性模型细胞膜的相互作用。细胞膜的主要组成部分是膦脂双层膜，因而细胞膜可以被认为是一个界面。从分子层面上原位地在水溶液的环境下阐述了各种材料包括药物分子，纳米材料，高分子，生物大分子与膦脂双层膜作用的机制，本文从非线性光谱-和频振动光谱角度予以综述。揭示了不同药物分子与不同模型细胞膜的不同作用。如一、阐述了抗菌药物分子是怎样破坏模型细胞膜的；二、揭示了氯丙嗪、金刚烷胺和美金刚与不同电性模型细胞膜作用时的相同及不同之处。和频振动光谱已成为一种研究药物分子与细胞膜相互作用的有力工具，可望用于研究中药与细胞膜的相互作用。

Abstract

The research goal is to elucidate molecular interactions between various drug molecules and cell membranes in situ. A nonlinear optical spectroscopic method

sum frequency generation (SFG) vibrational spectroscopy

was applied to investigate molecular interactions between antimicrobial compounds

chlorpromazine

amantadine

memantine and neutral or negatively charged model cell membranes. The different interactions between different drug molecules and different model cell membranes were successfully elucidated. For example

the molecular mechanisms of how antimicrobial compounds disrupt model cell membranes were revealed. The similarity and differences when chlorpromazine

amantadine

and memantine interact with model cell membranes with different charges were reported. SFG was developed into a powerful technique to study interactions between drug molecules and cell membranes

which can be applied to study interactions between Chinese medicine and cell membranes in the future.

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