Analysis of Calcium Element in Qingkailing Injection

YANG Wei; WU Si-yang; WANG Lu-di; KANG Chen; LI Ying-fei

doi:10.13422/j.cnki.syfjx.2017010075

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Analysis of Calcium Element in Qingkailing Injection

更新时间：2024-01-04

- Analysis of Calcium Element in Qingkailing Injection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 1, Pages: 75-78(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017010075
  CLC： R286.0
- Published：2017
- 稿件说明：
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YANG Wei, WU Si-yang, WANG Lu-di, et al. Analysis of Calcium Element in Qingkailing Injection[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 75-78.
DOI：

YANG Wei, WU Si-yang, WANG Lu-di, et al. Analysis of Calcium Element in Qingkailing Injection[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 75-78. DOI： 10.13422/j.cnki.syfjx.2017010075.

摘要

目的：通过对清开灵注射液组方药材、清开灵注射液和大鼠给药清开灵注射液后体内钙元素含量进行分析，明确清开灵注射液中钙元素的含量、主要来源和不同批次间的差异，推测钙元素是否是清开灵注射液的药效物质基础。方法：采用微波消解法对清开灵注射液、相关药材和大鼠给药清开灵注射液后的血浆样品进行处理，用电感耦合等离子体质谱（ICP-MS）法检测其中的钙元素，并结合相关信息学研究对结果进行分析。结果：明确了珍珠母和板蓝根是清开灵注射液组方药材钙元素的主要提供者，且进入到清开灵注射液中的钙元素不足组方药材钙元素质量分数的0.1%。不同批次清开灵注射液中钙元素差异相对差异>40%。大鼠尾静脉给予清开灵注射液后，血浆中的钙元素未有统计学意义上的变化。结论：清开灵注射液的制备工艺导致钙元素大量损失，且清开灵注射液中的钙元素未能引起大鼠血浆中钙元素浓度增加，因此钙元素是否是清开灵注射液的药效物质基础有待进一步研究。

Abstract

Objective: The calcium element in Qingkailing injection and its crude medicine were analyzed to clarify the calcium content

main source

differences between ten batches and whether calcium element is the pharmacodynamics material basis in Qingkailing injection. Method: The Qingkailing injection and crude medicine were prepared by microwave resolution method; the calcium element was detected by inductively coupled plasma-mass spectrometry (ICP-MS). Meanwhile the data was analyzed by relevant informatics research. Result: Concha margaritifera and Radix isatis were the major providers of calcium element in Qingkailing injection. The RSD of different batches Qingkailing injection was more than 40%. The concentration of plasma calcium element had no statistically significant differences after rat receiving intravenously Qingkailing injection compared to that of rats of control group. Conclusion: The modern preparing technology of Qingkailing injection lead to the loss of calcium

and the concentration of plasma calcium element was not increased by the calcium element of Qingkailing injection. Therefore

further research would be needed to understand whether the calcium element was the pharmacodynamics material basis of Qingkailing injection.

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