Excretion Pathway Analysis of Limonin in Rats

LIU Shi-jia; FENG Li-wen; DAI Guo-liang; HUANG Guo-dong; SUN Bing-ting; JU Wen-zheng

doi:10.13422/j.cnki.syfjx.2017010091

您当前的位置：

首页 >

文章列表页 >

Excretion Pathway Analysis of Limonin in Rats

更新时间：2024-01-04

- Excretion Pathway Analysis of Limonin in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 1, Pages: 91-94(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017010091
  CLC： R285.5
- Published：2017
- 稿件说明：
移动端阅览
LIU Shi-jia, FENG Li-wen, DAI Guo-liang, et al. Excretion Pathway Analysis of Limonin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 91-94.
DOI：

LIU Shi-jia, FENG Li-wen, DAI Guo-liang, et al. Excretion Pathway Analysis of Limonin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 91-94. DOI： 10.13422/j.cnki.syfjx.2017010091.

摘要

目的：考察柠檬苦素在大鼠体内的代谢途径，为阐明该药物的作用机制提供参考。方法：大鼠按80 mg·kg-1灌胃给予柠檬苦素，收集胆汁、尿液和粪便，利用HPLC和LC-MS/MS测定大鼠胆汁、尿液和粪便中柠檬苦素的含量，计算其累积排泄量和累积排泄分数。结果：柠檬苦素在大鼠粪便、尿液和胆汁中的累积排泄分数合计约50%，只有近一半的药物以原型形式排泄出体外。原药从尿液和胆汁中的总排泄量<1%，大部分以原型药物通过粪便排出。结论：柠檬苦素在大鼠体内的主要排泄途径为粪便，少量药物吸收进入血液后通过肝脏代谢，少量药物通过尿液排出体外。

Abstract

Objective: To investigate metabolic pathway of limonin in rats and its mechanism. Method: Bile

urine and feces of rats were collected after oral administration of limonin with dose of 80 mg·kg-1.HPLC and LC-MS/MS were used to determine the concentration of limonin in bile

urine and feces of rats

then calculated the cumulative excretion and cumulative fractional excretion. Result: Total cumulative fractional excretion of limonin in feces

urine and bile was about 50%

only about half of the drug was excreted in the form of prototype.Limonin excreted from the urine and bile was less than 1%.Most of limonin excluded through feces with prototype. Conclusion: Feces is major excretion pathway of limonin in rats after oral administration

only a small portion of the drug is absorbed into rat plasma.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis on Metabolites and Metabolic Pathways of Limonin in Rats by UHPLC-Q-Orbitrap HRMS

Pharmacokinetics Study of Hyperoside in Rats

Preparation and Pharmacokinetics in Rats of Nimodipine Nanostructured Lipid Carries

Identification of Metabolites of Rutin in Rats by UPLC-Q-TOF/MS

Related Author

LI Xuemin

GONG Qianqian

ZHENG Zhenxing

ZENG Li

ZHANG Mengjiao

DUAN Tingyin

LIU Xin

DENG Fang

Related Institution

School of Pharmacy，State Key Laboratory of Southwestern Chinese Medicine Resources， Key Laboratory of Standardization of Chinese Herbal Medicine，Ministry of Education， Chengdu University of Traditional Chinese Medicine

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰