Research Overview of Pharmacokinetic Study of Dammarane-type Ginsenoside

XU Li-yun; YANG Zhi-hong; SUN Xiao-bo

doi:10.13422/j.cnki.syfjx.2017010220

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Research Overview of Pharmacokinetic Study of Dammarane-type Ginsenoside

更新时间：2024-01-04

- Research Overview of Pharmacokinetic Study of Dammarane-type Ginsenoside
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 1, Pages: 220-227(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017010220
  CLC： R285.5
- Published：2017
- 稿件说明：
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XU Li-yun, YANG Zhi-hong, SUN Xiao-bo. Research Overview of Pharmacokinetic Study of Dammarane-type Ginsenoside[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 220-227.
DOI：

XU Li-yun, YANG Zhi-hong, SUN Xiao-bo. Research Overview of Pharmacokinetic Study of Dammarane-type Ginsenoside[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 220-227. DOI： 10.13422/j.cnki.syfjx.2017010220.

摘要

人参皂苷具有广泛的药理作用，对中枢神经系统、心血管系统、免疫系统、血液和造血系统等具有显著的药理作用。达玛烷型人参皂苷是人参属药材的主要药效成分，分为原人参二醇型和原人参三醇型2类。通过查阅近10年来国内外相关文献，对文献资料进行归纳和分析，分析人参皂苷Rb1，Rg1，Rc，Rd，Re等成分的药代动力学数据，发现达玛烷型人参皂苷的药代动力学过程与其结构密切相关。结构不同，2种类型的达玛烷型人参皂苷药代动力学过程存在显著差异。本文拟通过对原人参二醇型和原人参三醇型人参皂苷类成分的药物代谢动力学特征及二者的吸收、分布、代谢、排泄过程进行较为系统的梳理，为达玛烷型人参皂苷的深入研究提供参考。

Abstract

Ginsenoside has a wide range of pharmacological effects.It has obvious pharmacological effects on the central nervous system

cardiovascular system

immune system

blood and hematopoietic system and so on.Dammarane-type ginsenoside is one of the main effective components of Panax ginseng

and it consists of protopanaxadiol type and protopanaxatriol type.Referring to domestic and foreign research reports of dammarane-type ginsenoside in recent decades

we compare and analyze the literature data in aspects of absorption

distribution

metabolism and excretion.The pharmacokinetic data of ginsenoside Rb1

Rg1

Rd and Re are summarized.The pharmacokinetic profile and feature of dammarane-type ginsenoside are closely related to its chemical structure.There are significant differences between two dammarane ginsenoside types.This paper reviews the pharmacokinetic characteristics of the two dammarane ginsenoside types

in order to provide references for their further studies.

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