Research Progress on Chemical Constituents and Pharmacological Effects of

ZHOU Jian; ZHANG Chuang-feng; LYU Yan-ni; CHEN Fang-you; ZHANG Dong-ming; WEI Xiao-hua

doi:10.13422/j.cnki.syfjx.2017010228

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Research Progress on Chemical Constituents and Pharmacological Effects of

更新时间：2024-01-04

- Research Progress on Chemical Constituents and Pharmacological Effects of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 1, Pages: 228-234(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017010228
  CLC： R285;R284.1
- Published：2017
- 稿件说明：
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ZHOU Jian, ZHANG Chuang-feng, LYU Yan-ni, et al. Research Progress on Chemical Constituents and Pharmacological Effects of [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2017, 23(1): 228-234.
DOI：

ZHOU Jian, ZHANG Chuang-feng, LYU Yan-ni, et al. Research Progress on Chemical Constituents and Pharmacological Effects of [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2017, 23(1): 228-234. DOI： 10.13422/j.cnki.syfjx.2017010228.

摘要

截叶铁扫帚Lespedeza cuneata是豆科Leguminosae植物，在我国辽宁、吉林、黑龙江、山东、江苏、浙江、江西、湖北、湖南、四川、云南、福建、广东、广西、贵州等地均有分布，资源丰富。截叶铁扫帚在我国有着悠久的用药历史，常以地上部分入药，具有清热解毒、补肝肾、益肺阴、散淤消肿等功效。通过查阅中国知网，万方，SciFinder，PubMed，ScienceDirect等国内外多个数据库，对近年来关于截叶铁扫帚植物化学成分、生物活性及临床应用的相关文献进行归纳和总结，经全面分析后，分类归纳成综述。经系统文献调研发现，到目前为止已从截叶铁扫帚植物中分离鉴定了黄酮类化合物25个，酚酸类化合物12个，木脂素类化合物8个，单糖4个，其他类成分16个。现代药理研究表明，截叶铁扫帚及其化学成分具有保肝、抗菌、抗炎、抗氧化、植物夜感作用等多种生物活性，其中黄酮类成分具有很强的药理活性。另外，截叶铁扫帚作为民间药材，临床上常用于治疗糖尿病、血尿、失眠、小儿疳积等疾病。基于近年来国内外对截叶铁扫帚植物的研究，本文从化学成分、生物活性及临床应用等方面对截叶铁扫帚的研究现状进行了综述，以期能为进一步合理开发和综合利用截叶铁扫帚的药用资源提供参考。

Abstract

Lespedeza cuneata

a kind of plant of Leguminosae family

is widely distributed in northeast China

Shandong

Jiangsu

Zhejiang

Jiangxi

Hubei

Hunan

Sichuan

Yunnan

Fujian

Guangdong

Guangxi and Guizhou in China

with rich resources. This plant has a long medication history in China

and it is commonly used in the aerial parts with the function of heat-clearing and detoxifying

nourishing liver and kidney

benefiting lung

and scattering stasis and detumescence. By accessing CNKI

Wanfang date

SciFinder

PubMed

ScienceDirect

and multiple domestic and foreign databases

recent literature on chemical constituents

biological activity and clinical application L. cuneata were collected and summarized into a review. According to relevant domestic and foreign literature

65 compounds have been isolated from L. cuneata

including 25 flavonoids

12 phenolic acids

8 lignans

4 monosaccharides

and 16 other chemical constituents. Modern pharmacological research showed that L. cuneata and its chemical constituents showed diverse biological activities

such as hepatoprotective

antibacterial

anti-inflammatory

antioxidant

and nyctinastic leaf-movement effects. Particularly

flavonoids had a strong pharmacological activity. In addition

L. cuneata has been widely used as a folk medicine to treat diabetes

hematuria

insomnia

infantile malnutrition and other diseases. Based on the domestic and foreign studies on L. cuneata

the recent progress in the research on chemical constituents

biological activities and clinical applications of this plant was reviewed in this paper to provide reference for the further development and comprehensive utilization of L. cuneata medicinal resources.

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Related Institution

School of Traditional Chinese Medicine（TCM），Shanghai University of TCM

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Beicai Community Health Service Center of Pudong New Area

The Second Affiliated Hospital of Anhui University of Chinese Medicine

Anhui Province Key Laboratory of Research & Devolopment of Chinese Medicine

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