Objective: To observe the regulative effect of Nada mixture on the gastrointestinal motility and gastric myoelecerical activity in normal mice

as well as atropine and ephedrine-induced gastrointestinal motility disorder mice. Method: The 50 male ICR mice were randomly divided into normal group

Nada mixture low dose group

medium dose group

high dose group and domperidone group. Then

another 120 male ICR mice were randomly divided into normal group and model group. After injected with atropine or ephedrine hydrochloride in model group

mice were treated with normal saline

Nadal mixture of low

medium and high doses and domperidone to observe the effects of Nada mixture on gastrointestinal propulsion rate

gastric residual rate and slow wave of antral myoelectric in normal mice and model mice. Result: As compared with the normal mice

the model mice induced by atropine or ephedrine hydrochloride can significantly decrease gastrointestinal propulsion rate

increase the gastric residual rate

and suppress the frequency and amplitude of slow wave of gastric antrum smooth muscles. As compared with the model group

Nada mixture of each dose can significantly increase the gastrointestinal propulsion rate

promote the frequency and amplitude of slow wave of gastric antrum smooth muscles and reduce the gastric residual rate in a dose-dependent manner. Conclusion: Nada mixture can promote gastrointestinal motility and regulate gastric myoelecerical activity in mice.