Objective: To observe the compatible stability of Danhong injection combined with citicoline sodium injection (DHI+CSI) in two commonly used solvents (0.9% sodium chloride injection and 5% glucose injection). Method: The characters

pH values and insoluble particles of DHI+CSI in two solvents were observed and determined.The content changes of main compounds including danshensu

protocatechuic aldehyde

caffeic acid

p-coumaric acid

rosmarinic acid

salvianolic acid B and citicoline sodium in DHI and CSI were determined by UPLC. Result: The characters of DHI+CSI in the two commonly used solvents were brown

clarify and transparent liquid;pH values within 4 h were relatively stable;the numbers of insoluble particles were in the range of standards in 2015 edition of Chinese Pharmacopoeia.When the solvent was 0.9% sodium chloride injection

the content of caffeic acid reduced more than 50%;there were no significant changes of the contents of other compounds

and the contents of them were relatively stable within 4 h.When the solvent was 5% glucose injection

there were no significant changes of the contents of seven compounds in DHI and CSI

and the contents of them were relatively stable within 4 h. Conclusion: DHI and CSI can be combined in 0.9% sodium chloride injection and 5% glucose injection

and 5% glucose injection is preferred as the solvent.