Objective: To extract 24 trace elements from Moutan Corter such as Fe

Mn

Cu

Zn

Al

Pb

As and Cd by using decocting method. Method: Soluble state and suspension state in the extract were separated by 0.45 μm microporous filtering film. Soluble state was eluted from water and methanol by macrororous adsorption resin (LSA-10) in order to determine the inorganic state and organic state of the trace elements. In simulated human gastrointestinal solution

n-octylalcohol-water allocation system was used to separate water-soluble state and alcohol-soluble state for the trace elements. The total contents of the trace elements and various forms were detceted by inductively coupled plasma mass spectrometry (ICP-MS). Result: The recovery rate of this method was 74.7%-118.2%for all the elements

and precision RSD was 1.3%-6.9%. The extractive rate of the elements was 2.0%-82.9%

and the ratio of water-soluble state was 73.6%-99.5%. More than 80%of the trace elements in soluble state were in the form of inorganic state and water-soluble state. Conclusion: The morphological analysis and dissolution characteristics provide theoretical basis for clinical application of Moutan Corter.