Objective: To observe the protective effect of extract of Jujubae Fructus(EFJ) on iron deficiency anemia in rats. Method: The rats were fed iron deficiency diets for 6 weeks

and randomly divided into five groups based on hemoglobin (HGB) and weight:model group

low

medium and high-dose EFJ groups (2.7

5.4

10.8 g·kg-1) and ferrous sulfate group (100 mg·kg-1); And a normal group was set up. After continuous oral administration for 1

2

4 weeks

hematologic parameters red blood cell(RBC)

hematocrit(HCT)

HGB

mean corpuscular volume(MCV)

mean corpuscular hemoglobin(MCH)

mean corpuscular hemoglobin concentration (MCHC)

mean corpuscular hemoglobin concentration(CHCM)

hemoglobin concentration distribution width (HDW)

red cell distribution width(RDW)

platelet(PLT)

mean platelet volume(MPV) and plateletocrit(PCT) were investigated. Serum iron

total iron binding capacity

iron retention in liver and unsaturated iron binding capacity were also detected after administration for 4 weeks. Result: Compared with normal group

model group showed obvious decreases in HGB

RBC

HCT

MCH

MCHC

CHCM

increase in PLT (P<0.05

P<0.01)

significant reductions in serum iron

iron saturation

total iron binding capacity

iron retention in liver

and rise in unsaturated iron binding capacity (P<0.05

P<0.01). Compared with model group

low

medium and high-dose EFJ groups showed obvious increases in HGB

RBC

HCT

MCH

MCHC

CHCM

decrease in PLT and improvements in MCV

HDW

RDW

MPV

PCT in iron deficiency diet rats. Furthermore

it can significantly increase serum iron

iron saturation

total iron binding capacity

iron retention in liver (P<0.05

P<0.01). Conclusion: Extract of Jujubae Fructus can significantly improve iron deficiency anemia.