Objective: To study the Effect of Qianjin Gukang powder on tibia fracture model of rats. Method: Forty male SD rats with weight between 180-220 g

were selected. Except for the 10 rats in normal control group

the rest of 30 rats were injected with 2% pentobarbital sodium for anesthesia. Under aseptic conditions

the left lower limb tibia was cut at about 1 cm below tuberosity with bone shear to make 3 mm-wide and 2 mm-deep bone defect

so as to establish the tibia fracture model. The model rats were randomly divided into three groups

namely model group

and Qianjin Gukang powder low and high-dose groups (0.35

0.7 g·kg-1). Each group was respectively given drugs

with the dosing volume of 15 mL·kg-1

one time a day

for 21 days in a row. After the final administration

efforts were made to make X-ray imaging for the left tibia

collect blood for blood rheological test

and take the tibia bone scabs parts for histopathological examination. Result: Compared with normal group

model group showed mild callus changes

malposition

significantly increase in blood viscosity

and obvious pathological changes in fracture callus parts. Compared with model group

X-ray imaging showed Qianjin Gukang powder low and high-dose groups could obviously promote the fracture healing (P<0.05

P<0.01)

high-dose group could obviously reduce blood viscosity of rat tibia fracture model (P<0.05); both Qianjin Gukang powder low and high-dose groups can significantly transform histopathological changes in callus parts after fracture (P<0.05

P<0.01). Conclusion: Qianjin Gukang powder has a certain effect on promoting healing of rat tibia fractures.