Clinical Efficacy of Modified Shoutaiwan for Threatened Abortion with Uterine Hemorrhage

YU Pei-lin; WANG Jun-ling; LI Ya; CHEN Cui-mei; WANG Shuang-kui

doi:10.13422/j.cnki.syfjx.2017030155

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Clinical Efficacy of Modified Shoutaiwan for Threatened Abortion with Uterine Hemorrhage

更新时间：2024-01-04

- Clinical Efficacy of Modified Shoutaiwan for Threatened Abortion with Uterine Hemorrhage
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 3, Pages: 155-158(2017)
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- DOI：10.13422/j.cnki.syfjx.2017030155
  CLC： R271.9
- Published：2017
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YU Pei-lin, WANG Jun-ling, LI Ya, et al. Clinical Efficacy of Modified Shoutaiwan for Threatened Abortion with Uterine Hemorrhage[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(3): 155-158.
DOI：

YU Pei-lin, WANG Jun-ling, LI Ya, et al. Clinical Efficacy of Modified Shoutaiwan for Threatened Abortion with Uterine Hemorrhage[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(3): 155-158. DOI： 10.13422/j.cnki.syfjx.2017030155.

摘要

目的：观察寿胎丸加味方治疗早期妊娠先兆流产合并宫腔积血的临床疗效，并探讨其作用机制。方法：将146例中医辨证为肾虚血瘀型的先兆流产合并宫腔积血患者，随机分成治疗组和对照组，对照组单纯予地屈孕酮口服及黄体酮肌注，治疗组在对照组的基础上加用寿胎丸加味方进行治疗，两组疗程均为10 d，并随访至行胎儿颈项透明层（NT）检查，比较两组患者临床疗效、治疗前后中医临床症状积分，血清孕酮（P），雌二醇（E2）的变化情况及NT结果。结果：治疗组累积有效率为84.2%，优于对照组的70.0%（P<0.05）。治疗组治疗后所有中医临床症状积分均显著低于对照组（P<0.01）。治疗组治疗后血清P水平高于对照组（P<0.01）。两组NT结果差异无统计学意义，加用寿胎丸加味方并未引起胎儿畸形率的增高。结论：寿胎丸加味方能安全、有效治疗中医辨证为肾虚血瘀型的早期妊娠先兆流产合并宫腔积血。

Abstract

Objective: To observe the clinical efficacy of modified Shoutaiwan for threatened abortion with uterine hemorrhage in early pregnancy

and investigate its mechanism. Method: The 146 patients with threatened abortion with uterine hemorrhage in early pregnancy who were dialectical to deficiency of the kidney and blood stasis in traditional Chinese medicine (TCM) were randomly divided into treatment group and control group. Patients in control group took dydrogesterone tablets orally and progesterone by intramuscular injection. Patients in treatment group also received modified Shoutaiwan based on the treatment in control group. The treatment course lasted for ten days in both groups

and followed up until thenuchal translucency (NT) examination. The clinical efficacy

TCM symptom scores

progesterone (P) and estrodiol (E2) in serum and the result of NT were compared between two groups. Result: The cumulative effective rate was 84.2%in treatment group

higher than 70.0% in control group (P<0.05). All of the TCM symptom scores in the treatment group were much lower than those in the control group after treatment (P<0.01). The level of P in serum in the treatment group was higher than that in control group after treatment (P<0.01). There was no statistically significant difference in NT results between two groups and the use of modified Shoutaiwan did not cause the increased rate of fetal abnormalities. Conclusion: Modified Shoutaiwan can safely and effectively treat the patients with threatened abortion with uterine hemorrhage in early pregnancy who were dialectical to the deficiency of kidney and blood stasis in traditional Chinese medicine.

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