Primary immune thrombocytopenia(ITP)

which characterizes platelets decreasing

the body bleeding

the skin mucous membrane blood stasising and purple

epistaxis

and visceral hemorrhage

is an autoimmune disease. ITP animal model is the main method of studying the pathogenesis and treatment of ITP

and has played an important role in the study of ITP. Therefore

how to create and close to the clinical animal model is the key issue in the field of ITP research. At present

there are many methods to create the animal model of ITP

such as injecting anti-plateletserum or platelet

transgenic models

Spontaneous immune models

transgenic modeling and other modeling methods. Immunological modeling is the most commonly used method

the experimental animals are mainly mice

commonly used injection is intraperitoneal injection

commonly used immunogen anti-platelet serum

monoclonal/polyclonal antibodies

platelets

spontaneous model and transgenic model use less. In addition disease and syndrome combination models with heat syndrome

Kidney yin deficiency syndrome and syndrome of qi failing to control blood. The research progress of ITP in disease models and model of disease and syndrome combination will be summarized and analyzed in this article

and to provide reference for further study of ITP animal models.