Progress and cause analysis of adverse reactions of Polygoni Multiflori Radix preparations were studied to conduct follow-up researches from the perspective of the effect of preparations in toxic expression and provide research ideas. Relevant literatures in recent years were consulted to study Polygoni Multiflori Radix preparations for their adverse reactions and toxicity mechanism and other aspects

in order to summarize and analyze the causes. In terms of components

Polygoni Multiflori Radix mainly containing stilbene

lecithin

anthraquinones

tannins

trace elements and other ingredients

with stilbene glucoside and anthraquinone class as its main active ingredients

which indicated the possible material basis of Polygoni Multiflori Radix toxicity; with respect to processing

processing methods had effects on the chemical composition of Polygoni Multiflori Radix

as evidenced by significant differences in Polygoni Multiflori Radix blood profiles before and after processing

which caused different liver substance metabolic mechanisms in rats. By dosage and usage

long-term intake of high-dose Polygoni Multiflori Radix can cause reversible liver damage

which was mainly reflected in liver function abnormalities. In terms of compound compatibility

it was still uncertain whether different combinations would result in Polygoni Multiflori Radix adverse reactions. Clinical adverse reactions of Polygoni Multiflori Radix preparations suggest toxic and side effects that cannot be ignored on liver. Modern preparation process may be one of the causes for the adverse reactions

but its regularity characteristics causing liver toxicity

mechanism of action and material basis were still unclear yet. In addition to the chemical constituents in Polygoni Multiflori Radix and the attenuating mechanism of processing

efforts shall be made to actively explore the impact of the effect of pharmaceutical process of Polygoni Multiflori Radix on its hepatotoxicity. In addition to strengthening safety evaluation of Polygoni Multiflori Radix preparations

efforts shall be made to actively study the effect of pharmaceutical processing

compound compatibility and drug interactions on hepatotoxic effects and explore rational clinical drug use patterns

in order to minimize the adverse reactions caused by taking of Polygoni Multiflori Radix preparations.