Analysis on Change Law of Chemical Constituents in Phellodendri Amurensis Cortex Before and After Being Processed

YUE Lin; LI Li; LIU Ying; XIAO Yong-qing

doi:10.13422/j.cnki.syfjx.2017050007

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Analysis on Change Law of Chemical Constituents in Phellodendri Amurensis Cortex Before and After Being Processed

更新时间：2024-01-04

- Analysis on Change Law of Chemical Constituents in Phellodendri Amurensis Cortex Before and After Being Processed
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 5, Pages: 7-11(2017)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2017050007
  CLC： R284.1
- Published：2017
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YUE Lin, LI Li, LIU Ying, et al. Analysis on Change Law of Chemical Constituents in Phellodendri Amurensis Cortex Before and After Being Processed[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 7-11.
DOI：

YUE Lin, LI Li, LIU Ying, et al. Analysis on Change Law of Chemical Constituents in Phellodendri Amurensis Cortex Before and After Being Processed[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 7-11. DOI： 10.13422/j.cnki.syfjx.2017050007.

摘要

目的：探究关黄柏炒炭前后饮片化学成分的变化规律，为关黄柏和关黄柏炭饮片的质量标准制定提供依据。方法：采用HPLC测定，流动相乙腈-0.4 mol·L-1氯化铵水溶液梯度洗脱，柱温35℃，流速1.0 mL·min-1，检测波长215 nm。分析关黄柏炒炭前后饮片化学成分组成及含量的变化，对其中7种主要化学成分进行定量分析。结果：10批关黄柏饮片中，木兰花碱、盐酸黄柏碱、盐酸药根碱、盐酸巴马汀、盐酸小檗碱、黄柏内酯、黄柏酮的质量分数分别为2.468~6.783，1.947~4.197，0.209~0.506，3.049~4.557，5.869~13.168，5.141~7.337，1.798~4.975 mg·g-1。关黄柏炒炭后，除个别企业样品外，各化学成分含量均有减少，其中盐酸小檗碱、盐酸巴马汀等生物碱类成分几乎殆尽；黄柏酮、黄柏内酯等小极性成分保存较多，9批关黄柏炭饮片中，黄柏内酯、黄柏酮的质量分数分别为3.164~6.483，0.281~1.614 mg·g-1。结论：关黄柏饮片炒炭后，外观性状和内在成分变化明显，关黄柏饮片的质量标准难以应用于关黄柏炭。所购关黄柏炭饮片也因此难以做到炒炭程度统一，应根据关黄柏炒炭后的成分变化规律控制炒炭程度，进一步规范关黄柏和关黄柏炭饮片的质量标准。

Abstract

Objective: To discuss the change law of chemical constituents in Phellodendri Amurensis Cortex before and after being processed

and to provide the basis for the quality standard of its decoction pieces.Method: HPLC was performed by taking acetonitrile-0.4 mol·L-1 ammonium chloride solution as mobile phase

column temperture at 35℃

the flow rate of 1.0 mL·min-1 and the detection wavelength of 215 nm.Chemical constituents in Phellodendri Amurensis Cortex before and after being processed was analyzed and 7 main constituents were measured.Result: Among 10 batches of Phellodendri Amurensis Cortex decoction pieces

the contents of magnoflorine

phellodendrine

jatrorrhizine

palmatine

berberine

obaculactone and obakunone were 2.468-6.783

1.947-4.197

0.209-0.506

3.049-4.557

5.869-13.168

5.141-7.337

1.798-4.975 mg·g-1.After being processed

in addition to a sample

all the constituents reduced

among which alkaloids like berberine and palmatine

almost disappeard

however

obakunone and obaculactone existed.Among 9 batches of Phellodendri Amurensis Cortex decoction pieces

the contents of obaculactone and obakunone were 3.164-6.483

0.281-1.614 mg·g-1.Conclusion: The appearance and internal components of Phellodendri Amurensis Cortex after being processed obviously change.The quality standard

which applies to Phellodendri Amurensis Cortex

can't apply to charred Phellodendri Amurensis Cortex decoction pieces.So the process degree of samples is different

the process degree should be controlled according to the laws.

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