Release and Transdermal Absorption Properties of Huoxue Zhitong Microemulsion Gels

HE Ai-ping; YI Hong; FENG Wei-hong; YAO Yao; DU Mao-bo; LIU Shu-zhi

doi:10.13422/j.cnki.syfjx.2017050017

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Release and Transdermal Absorption Properties of Huoxue Zhitong Microemulsion Gels

更新时间：2024-01-04

- Release and Transdermal Absorption Properties of Huoxue Zhitong Microemulsion Gels
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 5, Pages: 17-21(2017)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2017050017
  CLC： R285.5
- Published：2017
- 稿件说明：
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HE Ai-ping, YI Hong, FENG Wei-hong, et al. Release and Transdermal Absorption Properties of Huoxue Zhitong Microemulsion Gels[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 17-21.
DOI：

HE Ai-ping, YI Hong, FENG Wei-hong, et al. Release and Transdermal Absorption Properties of Huoxue Zhitong Microemulsion Gels[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 17-21. DOI： 10.13422/j.cnki.syfjx.2017050017.

摘要

目的：研究活血止痛微乳凝胶的体外释放和透皮吸收特性，为该制剂的研发提供参考。方法：采用改良Franz扩散池装置，分别以半透膜和离体小鼠皮肤为体外模型，采用UPLC同时测定接收液和皮肤中丹皮酚、丁香酚和水杨酸甲酯的含量，流动相乙腈（A）-0.1%甲酸水溶液（B）梯度洗脱（0~4 min，10%~90% A），检测波长280 nm，流速0.6 mL·min-1，进样量1 μL。结果：活血止痛微乳凝胶中丹皮酚、丁香酚和水杨酸甲酯在6 h内的累积释放率分别为70.35%，59.40%，54.64%，释放速率分别为1.138，11.57，73.54 μg·cm-2·h-1；体外透皮试验6 h累积透过率分别为40.34%，36.34%，41.44%，透过速率分别为0.657，7.127，56.04 μg·cm-2·h-1。结论：活血止痛微乳凝胶具有较好的体外释放和透皮性能，体外释放符合Higuchi方程，经皮渗透行为符合零级动力学方程。

Abstract

Objective: To study on in vitro release and transdermal absorption properties of Huoxue Zhitong microemulsion gels.Method: Improved Franz diffusion cell was adopted to investigate in vitro release in semipermeable membrane and transdermal absorption in mouse skin of Huoxue Zhitong microemulsion gels.The contents of paeonol

eugenol and methyl salicylate in receptor fluid were determined by UPLC.Result: In 6 hours

the cumulative release rates of paeonol

eugenol and methyl salicylate were 70.35%

59.40% and 54.64%

the transmission rates of them were 1.138

11.57

73.54 μg·cm-2·h-1

respectively.In 6 hours

the accumulative permeation rates of paeonol

eugenol and methyl salicylate were 40.34%

36.34% and 41.44%

the release rates of them were 0.657

7.127

56.04 μg·cm-2·h-1

respectively.Conclusion: Huoxue Zhitong microemulsion gels has a good in vitro release and transdermal properties

the release laws of all indexes are in accordance with Higuchi equation and the transdermal actions are consistent with zero-order kinetic equation.

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