QIU Li-li, DING Ju-ying, DU Mao-bo. Optimization of Extraction and Molding Process of Xiao'er Wenli Zhixie Plaster[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 32-36.
DOI:
QIU Li-li, DING Ju-ying, DU Mao-bo. Optimization of Extraction and Molding Process of Xiao'er Wenli Zhixie Plaster[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 32-36. DOI: 10.13422/j.cnki.syfjx.2017050032.
Optimization of Extraction and Molding Process of Xiao'er Wenli Zhixie Plaster
Objective: To optimize the extraction process of Xiao'er Wenli Zhixie plaster by supercritical CO2 fluid extraction technology and its matrix prescription.Method: Extracting amount of cinnamaldehyde was selected as the indictor
L9(34) orthogonal test was used to optimize supercritical CO2 fluid extraction technology of Xiao'er Wenli Zhixie plaster.Initial viscosity
peel strength and cohesive strength were selected as indictors
L9(34) orthogonal test was used to optimize matrix prescription.The uniformity of Xiao'er Wenli Zhixie plaster was investigated by the uniformity test.Result: Optimum extraction parameters were as follows:extraction temperature at 45℃
extraction pressure of 50 MPa
extraction time of 2.5 h
flow rate of CO2 of 20 kg·h-1.Optimum matrix prescription was as follow:polyvinyl alcohol-sodium polyacrylate-glycerol-carboxy methyl cellulose sodium (0.6:2.5:1.0:1.0).This prescription showed satisfactory performance of initial viscosity
peel strength and cohesive strength;its uniformity was 15
which was in line with regulation in the 2015 edition of Chinese Pharmacopoeia.Conclusion: The optimized extraction process is stable and available.The optimum matrix prescription of is simple and stable
which can be applied to industrial production of Xiao'er Wenli Zhixie plaster.
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Related Author
Ming-xia CHEN
Jian-xun LIU
Qu-xing WU
Pan WANG
Zeng-lin LIAN
Ye LIU
Zhi-gang LI
Jun-guo REN
Related Institution
Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia Medica
Institute of Traditional Chinese Medicine, Beijing Han Dian Pharmaceutical Co. Ltd
Guangzhou University of Traditional Chinese Medcine