Mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma Based on Network Pharmacology

WU Jia-rui; JIN Yan-ping; DUAN Xiao-jiao; LIU Shi; ZHANG Bing

doi:10.13422/j.cnki.syfjx.2017050184

您当前的位置：

首页 >

文章列表页 >

Mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma Based on Network Pharmacology

更新时间：2024-01-04

- Mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma Based on Network Pharmacology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 5, Pages: 184-188(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2017050184
  CLC： R285
- Published：2017
- 稿件说明：
移动端阅览
WU Jia-rui, JIN Yan-ping, DUAN Xiao-jiao, et al. Mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 184-188.
DOI：

WU Jia-rui, JIN Yan-ping, DUAN Xiao-jiao, et al. Mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma Based on Network Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 184-188. DOI： 10.13422/j.cnki.syfjx.2017050184.

摘要

目的：探讨桔梗-甘草药对的功效物质基础和配伍机制。方法：从中药系统药理学分析平台（TCMSP）中寻找与这两味中药相关的所有化学成分。选择口服利用度（OB）≥50%，类药性（DL）≥0.18作为化合物分子的筛选条件。通过中药系统药理学分析平台（TCMSP）寻找与候选化合物相关的潜在靶点，进而构建药物靶点相互作用的网络图和靶点疾病相互作用网络图。结果：通过OB，DL条件筛选，得出43个候选活性分子，相应靶点有98个，相关疾病有224种。其度值前三的候选化合物分子分别是柚皮素（48），芒柄花黄素（41），shinpterocarpin（36）；度值前三的靶点蛋白为PTGS2（32），PPAR-γ（21），ERS1（18）；度值较高的相关疾病依次是非特异性癌症、炎症、痛症、乳癌、阿尔茨海默症等。结论：研究结果初步验证了该药对的基本药理学作用和相关机制，并为进一步深入探讨作用机制奠定了良好基础。

Abstract

Objective: To investigate the efficacy material basis and the compatibility mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma.Method: All the chemical components related to the two traditional Chinese herbs from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) were searched. The oral bioavailability (OB)≥50% and drug likeness (DL)≥0.18 were used as the screening conditions for molecular compounds. The potential targets related to candidate compounds were found through the TCMSP

and then the drug-target interaction network as well as target-disease interaction network were constructed.Result: The 43 candidateactive molecules

98 corresponding targets and 224 related diseases were obtained through screening according to OB and DL conditions. The top three compounds were arenaringenin (48)

formononetin (41) and shinpterocarpin (36). The top three target proteins were PTGS2 (32)

PPAR-γ (21) and ERS1 (18). Related diseases of higher degree values were non-specific cancer

inflammation

pain

breast cancer and Alzheimer's disease and so on.Conclusion: The results of the study preliminarily verified the basic pharmacological effects and related mechanisms of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma

and laid a good foundation for further study on the mechanism of action.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Network Pharmacology on Interaction of Effective or Toxic Components of Kansui Radix and Glycyrrhizae Radix et Rhizoma

Metabolomics-based Analysis of Toxicity Changes of Aconiti Lateralis Radix Praeparata-Zingiberis Rhizoma in Sinitang Before and After Compatibility

Pharmacological Effect of Glycyrrizae Radix et Rhizoma Compatibility and Its Mechanism

Protective Effect of Glycyrrhizae Radix et Rhizoma-Granati Pericarpium Formula on Ultraviolet-induced Skin Damage

Investigation on Anti-liver Cancer Potential and Compatibility Characteristics of Fufang Biejia Ruangan Pian from Network Perspective

Related Author

LIU Hong

FAN Xin-sheng

PENG Wei

LIU Dongmei

FU Shu

WANG Xiao

WU Mingquan

HE Pilong

Related Institution

School of Pharmacy，Chengdu University of Traditional Chinese Medicine

Sichuan Province Orthopedic Hospital

Zigong First People's Hospital

ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research，Guangxi University of Chinese Medicine

Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica， Guangxi University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰