TAO Ling, XIAO Fang, ZHU Wei-feng, et al. Attenuation Effect of Tripterygii Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 229-234.
DOI:
TAO Ling, XIAO Fang, ZHU Wei-feng, et al. Attenuation Effect of Tripterygii Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(5): 229-234. DOI: 10.13422/j.cnki.syfjx.2017050229.
Attenuation Effect of Tripterygii Radix et Rhizoma
Tripterygii Radix et Rhizoma is a kind of commonly used traditional Chinese medicine (TCM) in treating rheumatoid arthritis
with multiple pharmacological effects
including heat-clearing and detoxifying
eliminating wind and dampness
detumescence and analgesia
parasite destroy and itching relieving. According the development of modern pharmacological research
it shows anti-inflammatory
analgesic
anti-tumor and immune regulatory effects
and has been clinically applied to treat immune diseases
renal disease and dermatosis disease
particularly for rheumatoid arthritis. However
due to its multi-organ toxicity
especially hepatotoxicity and nephrotoxicity
it has been restricted from being widely used in clinic
which has become a hot research topic in recent years. Our research group focused on the attenuation and synergy effect of Tripterygii Radix et Rhizoma through transdermal drug delivery
in order to promote application of Tripterygii Radix et Rhizoma. This paper collects and analyzes relevant literatures from 2006 to 2016
including traditional processing for attenuation
combined administration for attenuation
modern preparations for attenuation
structural modification for attenuation
biological technology for attenuation and their combined applications. By analysis of the current conditions and difficulties in developing the attenuation and synergy of Tripterygii Radix et Rhizoma and comparing the differences with the existing attenuation modes
this study provides ideas for further studies on attenuation and synergy of Tripterygii Radix et Rhizoma
promote the rational development and safe clinical application
and offers a reference for the rational application of other toxic TCMs.
Effect of Tripterygii Radix et Rhizoma Combined with Paeoniae Radix Alba on Transdermal Absorption of Tripterygii Radix et Rhizoma Extract
Evaluation on Mutual Detoxication of Compatibility of Tripterygii Radix et Rhizoma and Lysimachiae Herba Based on Principal Component Analysis
Combination of Components from Tripterygii Radix et Rhizoma-Chuanxiong Rhizoma Affects RA-FLSs by Regulating NF-κB, Nrf2/HO-1 Signaling Pathways and Bcl-2/Caspase-3 Expression
Study of Triptolide on Liver Injury and Detoxification Strategy
Chronic Toxicity of Triptolide and Ferulic Acid Ethosomes Gel for Percutaneous Administration
Related Author
WANG Jun-ming
LI Jin-hua
LI Jin-yang
CAI Hong
ZHANG Yue-yue
RONG Chun-lei
LI Jun
CUI Ying
Related Institution
Laboratory Animal Science and Technology Center,Jiangxi University of Chinese Medicine
National Key Laboratory of Modern Chinese Medicine Creation of Classic Prescriptions
Jiangxi University of Chinese Medicine,Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education
School of Life Science,Beijing University of Chinese Medicine
Key Laboratory of Modern Preparation of Traditional Chinese Medicine Under Ministry of Education, Jiangxi University of Chinese Medicine