XUE Yu-chen, SU Ju, JIANG Feng, et al. Preparation of Scutellarin Sustained-release Microspheres and Study on Its Pharmaceutical Properties[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(6): 7-12.
DOI:
XUE Yu-chen, SU Ju, JIANG Feng, et al. Preparation of Scutellarin Sustained-release Microspheres and Study on Its Pharmaceutical Properties[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(6): 7-12. DOI: 10.13422/j.cnki.syfjx.2017060007.
Preparation of Scutellarin Sustained-release Microspheres and Study on Its Pharmaceutical Properties
Objective: To select the best formula and technology for the preparation of scutellarin sustained-release microspheres and study on its pharmaceutical properties. Method: S/O/W emulsification solvent evaporation method was adopted to prepare scutellarin sustained-release microspheres
taking composite score of drug loading
encapsulation efficiency and yield as index
orthogonal test was used to optimize preparation process of scutellarin sustained-release microspheres and its in vitro release was investigated.This microspheres was charaterized in some ways
such as laser particle size analyzer
scanning electron microscopy
Fourier transform infrared spectroscopy and X-ray diffraction. Result: Optimum preparation process was as following:scutellarin dosage of 25 mg
poly(lactide-glycolide acid) (PLGA) amount of 200 mg
polyvinyl alcohol (PVA) amount of 1.0%
dichloromethane-acetone (1.7:0.3)
stirring speed of 1 000 r·min-1.The drug loading
encapsulation efficiency and yield were (6.18±0.11)%
(50.79±2.01)% and (91.18±2.19)%
respectively;in vitro cumulative release of 30% needed ≥600 h
average particle size was (126.0±2.10) μm.The surface of scutellarin sustained-release microspheres was round without adhesion.The internal of microspheres had some crystals of scutellarin.FT-IR and XRD indicated that scutellarin still existed in the form of crystals. Conclusion: Sustained-release microspheres of scutellarin is successfully prepared with emulsification solvent evaporation method.This optimized process is simple and reasonable
which is basis for further research of scutellarin preparations.
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Related Institution
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