Clinical Observation on Method of Supplementing Qi, Resolving Phlegm and Activating Blood Circulationin Improving Disorder of Glucose and Lipid Metabolism and Obestatin in Overweight/Obese of Type 2 Diabetes Mellitus Patients

SUN Lu; TANG Xian-yu; ZHANG Peng; HE Liu; HE Jia-li; LIANG Qi-ting; XIE Wen-wen; FAN Guan-jie

doi:10.13422/j.cnki.syfjx.2017060181

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Clinical Observation on Method of Supplementing Qi, Resolving Phlegm and Activating Blood Circulationin Improving Disorder of Glucose and Lipid Metabolism and Obestatin in Overweight/Obese of Type 2 Diabetes Mellitus Patients

更新时间：2024-01-04

- Clinical Observation on Method of Supplementing Qi, Resolving Phlegm and Activating Blood Circulationin Improving Disorder of Glucose and Lipid Metabolism and Obestatin in Overweight/Obese of Type 2 Diabetes Mellitus Patients
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 23, Issue 6, Pages: 180-185(2017)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2017060181
  CLC： R587.1;R589.2
- Published：2017
- 稿件说明：
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SUN Lu, TANG Xian-yu, ZHANG Peng, et al. Clinical Observation on Method of Supplementing Qi, Resolving Phlegm and Activating Blood Circulationin Improving Disorder of Glucose and Lipid Metabolism and Obestatin in Overweight/Obese of Type 2 Diabetes Mellitus Patients[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(6): 180-185.
DOI：

SUN Lu, TANG Xian-yu, ZHANG Peng, et al. Clinical Observation on Method of Supplementing Qi, Resolving Phlegm and Activating Blood Circulationin Improving Disorder of Glucose and Lipid Metabolism and Obestatin in Overweight/Obese of Type 2 Diabetes Mellitus Patients[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(6): 180-185. DOI： 10.13422/j.cnki.syfjx.2017060181.

摘要

目的：观察益气化痰活血法对气虚痰瘀型超重/肥胖2型糖尿病糖脂代谢及肥胖抑制素的影响，并探讨其作用机制。方法：86例超重/肥胖2型糖尿患者随机分为治疗组和对照组，各43例，治疗组采用益气化痰活血中药+基础治疗，对照组采用安慰剂+基础治疗；治疗前后分别检测空腹血糖、餐后2 h血糖、空腹胰岛素、糖化血红蛋白、血脂、肥胖抑制素（obestatin），安全性指标（三大常规、肝肾功能），计算胰岛素抵抗指数（HOMA-IR），并详细观察患者症状、体征的变化以及药物的毒副反应。结果：治疗后治疗组中医疗效优于对照组（P<0.05），可以明显改善少气乏力/懒言、口干不多饮、肢体麻木或刺痛等症状；治疗后与对照组比较，治疗组体质量指数、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数明显下降（P<0.05），obestatin明显升高（P<0.05），治疗组胆固醇、低密度脂蛋白显著下降（P<0.01），高密度脂蛋白显著升高（P<0.01）；两组治疗后空腹血糖、甘油三酯比较差异无统计学意义。结论：益气化痰活血法可以改善治疗组患者糖脂代谢紊乱、胰岛素抵抗，提升obestatin水平，这可能是益气化痰活血中药复方发挥作用的途径之一。

Abstract

Objective: To observe the effect of method of Supplementing Qi

Resolving Phlegm and Promoting Blood Circulation on glucose and lipid metabolism and obestatin in obesity type 2 diabetes mellitus

and investigate its action mechanism. Method: The 86 cases of overweight/obese patients with type 2 diabetes were randomly divided into treatment group and control group

each consisting of 43 cases. Patients in treatment group received traditional Chinese medicine (supplementing Qi

resolving phlegm and activating blood circulation)+basic therapy

and patients in control group received placebo+basic therapy. Both before and after treatment

the fasting blood glucose

postprandial 2 h plasma glucose

fastinginsulin

glycosylated hemoglobin

blood lipids

obestatin

safety indexes (three routine tests

liver and kidney function) were detected; the insulin resistance indexes (HOMA-IR)were calculated

and changes in symptoms

signs and drug adverse reactions were observed in detail. Result: The curative effect of traditional Chinese medicine in treatment group was better than that in control group after treatment(P<0.05)

and it can significantly improve the shortness of breath and fatigue/lazy words

drying mouth and polydipsia

limbs numbness or tingling

and other symptoms. After treatment

the body mass index

2 h postprandial blood glucose

glycosylated hemoglobin

and insulin resistance index in treatment group were lower than those in control group(P<0.05)

while the level of obestatin was higher than that in control group (P<0.05); the levels of cholesterol and low density lipoprotein in treatment group were significantly lower than those in control group (P<0.01)

while the level of high density lipoprotein was significantly higher than that in control group(P<0.01); there were no statistically significant differences in fasting blood glucose and triglyceride between two groups after the treatment. Conclusion: The method of Supplementing Qi

Resolving Phlegm and Promoting Blood Circulation can improve glucose and lipid metabolism disorder

insulin resistance and obestatin level in treatment group

which may be one of the active ways for Chinese herbal compound of supplementing Qi

resolving phlegm and activating blood circulation.

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